Toxicokinetic assessment of methylphenidate (Ritalin®) in a 13-week oral (gavage) toxicity study in rats using an enantiomeric liquid chromatography/tandem mass spectrometry assay

被引:6
|
作者
Bakhtiar, R [1 ]
Tse, FLS [1 ]
机构
[1] Merck & Co Inc, Rahway, NJ 07065 USA
关键词
D O I
10.1002/rcm.1167
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:2160 / 2162
页数:3
相关论文
共 49 条
  • [1] Toxicokinetic assessment of methylphenidate (Ritalin®) in a 13-week oral toxicity study in dogs
    Bakhtiar, R
    Ramos, L
    Tse, FLS
    BIOMEDICAL CHROMATOGRAPHY, 2004, 18 (01) : 45 - 50
  • [2] Quantification of methylphenidate (Ritalin®) in rabbit fetal tissue using a chiral liquid chromatography/tandem mass spectrometry assay
    Bakhtiar, R
    Ramos, L
    Tse, FLS
    RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2002, 16 (01) : 81 - 83
  • [3] Toxicokinetic studies of methylphenidate (Ritalin®) in rat, rabbit, and dog using an enantioselective liquid-chromatography/tandem mass spectrometry technique.
    Bakhtiar, R
    Ramos, L
    Aram, S
    Tse, FLS
    FASEB JOURNAL, 2000, 14 (08): : A1479 - A1479
  • [4] Preclinical safety assessment of Angelica acutiloba using a 13-week repeated dose oral toxicity study in rats
    Yun J.-W.
    Kwon E.
    Kim S.-H.
    You J.-R.
    Kim Y.-S.
    Park I.A.
    Kim H.H.
    Che J.-H.
    Kang B.-C.
    Laboratory Animal Research, 2017, 33 (3) : 223 - 230
  • [5] Liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry enantiomeric separation of dl-threo-methylphenidate, (Ritalin®) using a macrocyclic antibiotic as the chiral selector
    Ramos, L
    Bakhtiar, R
    Majumdar, T
    Hayes, M
    Tse, F
    RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1999, 13 (20) : 2054 - 2062
  • [6] Quantification of methylphenidate in rat, rabbit and dog plasma using a chiral liquid-chromatography/tandem mass spectrometry method - Application to toxicokinetic studies
    Bakhtiar, R
    Ramos, L
    Tse, FLS
    ANALYTICA CHIMICA ACTA, 2002, 469 (02) : 261 - 272
  • [7] Liquid-liquid extraction using 96-well plate format in conjunction with liquid chromatography/tandem mass spectrometry for quantitative determination of methylphenidate (Ritalin®) in human plasma
    Ramos, L
    Bakhtiar, R
    Tse, FLS
    RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2000, 14 (09) : 740 - 745
  • [8] The Pseudotargeted Metabolomics Study on the Toxicity of Fuzi Using Ultraperformance Liquid Chromatography Tandem Mass Spectrometry
    Wu, Huifei
    Zhang, Wenxia
    Lin, Hui
    Ye, Qiuming
    Guo, Jiayin
    Quan, Shijian
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022
  • [9] Pharmacokinetics and bioavailability assessment of Miltefosine in rats using high performance liquid chromatography tandem mass spectrometry
    Valicherla, Guru R.
    Tripathi, Priyanka
    Singh, Sandeep K.
    Syed, Anees A.
    Riyazuddin, Mohammed
    Husain, Athar
    Javia, Deep
    Italiya, Kishan S.
    Mishra, Prabhat R.
    Gayen, Jiaur R.
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 1031 : 123 - 130
  • [10] Safety assessment of astaxanthin derived from engineered Escherichia coli K-12 using a 13-week repeated dose oral toxicity study and a prenatal developmental toxicity study in rats
    Lin, Yin-Ju
    Lin, Jian-Yu
    Wang, Di-Sheng
    Chen, Chien-Hao
    Chiou, Ming-Hsi
    REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2017, 87 : 95 - 105