Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent

被引：68

作者：

Ahn, KS

Hahm, MS

Park, EJ

Lee, HK

Kim, IH

机构：

[1] Korea Univ, Grad Sch Biotechnol, Sungbuk Ku, Seoul 136701, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Taejon, South Korea

来源：

PLANTA MEDICA | 1998年 / 64卷 / 05期

关键词：

D O I：

10.1055/s-2006-957487

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Corosolic acid isolated from the fruit of Crataegus pinnatifida var, psilosa was tested for anticancer activity. Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of K-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose-dependent pattern in an in vitro PKC assay.

引用

页码：468 / 470

页数：3

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