Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta

被引：81
作者：
Batocchi, AP
Rotondi, M
Caggiula, M
Frisullo, G
Odoardi, F
Nociti, V
Carella, C
Tonali, PA
Mirabella, M
机构：
[1] Catholic Univ, Neurol Inst, I-00168 Rome, Italy
[2] Univ Naples, F Magrassi Inst Endocrinol II, Dept Clin & Expt Med, I-80121 Naples, Italy
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 139卷 / 1-2期
关键词：
leptin; cytokines; multiple sclerosis; interferon beta;
D O I：
10.1016/S0165-5728(03)00154-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of leptin was investigated in relapsing-remitting multiple sclerosis (MS). Control and MS patients showed comparable baseline serum leptin levels. During the first year of IFNbeta-1a treatment, leptin significantly decreased since 2 months after starting therapy in 11 patients who had no relapses. A significant decrease in IL12/IL10 ratio was observed in this group of patients only after I year of treatment. An increase of leptin was observed before the first clinical exacerbation in 13 relapsing patients. Leptin may play a pathogenic role in MS and can be a useful marker of disease activity and response to therapy. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：150 / 154
页数：5
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