Periodontal disease measures and risk of incident peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) Study

被引:5
作者
Arsiwala, Lubaina T. [1 ]
Mok, Yejin [2 ]
Yang, Chao [2 ]
Ishigami, Junichi [2 ]
Selvin, Elizabeth [2 ]
Beck, James D. [3 ,4 ]
Allison, Matthew A. [5 ]
Heiss, Gerardo [4 ]
Demmer, Ryan T. [6 ]
Matsushita, Kunihiro [2 ]
机构
[1] Johns Hopkins Sch Med, Wilmer Eye Inst, Baltimore, MD USA
[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 2024 E Monument St, Baltimore, MD 21287 USA
[3] Univ N Carolina, Div Comprehens Oral Hlth Periodontol, Adams Sch Dent, Chapel Hill, NC 27515 USA
[4] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA
[5] Univ Calif San Diego, Dept Family Med, San Diego, CA 92103 USA
[6] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA
基金
美国国家卫生研究院;
关键词
cohort studies; periodontal diseases; peripheral arterial disease; tooth loss; CORONARY-HEART-DISEASE; TOOTH LOSS; VASCULAR-DISEASE; 3RD MOLARS; ASSOCIATION; PATHOGENS; IDENTIFICATION; POPULATION; INFECTIONS; VALIDATION;
D O I
10.1002/JPER.21-0342
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Background The association of periodontal disease with atherosclerotic cardiovascular diseases is well known, but not specifically with incident peripheral artery disease (PAD). Therefore, we studied the associations of periodontal disease with incident PAD in a population-based setting. Methods Among 9,793 participants (aged 53-75 years) without prevalent PAD, self-reported history of periodontal disease was ascertained. Of these, 5,872 participants underwent full-mouth examinations from which periodontal status was defined using the US Centers for Disease Control and Prevention-American Academy of Periodontology (CDC-AAP) definition. We quantified the association of periodontal disease with incident PAD (defined by hospital admission diagnosis or procedures) using multivariable Cox regression models. Results During a median follow-up of 20.1 years, 360 participants (3.6%) developed PAD. In models accounting for potential confounders including diabetes and smoking pack-years, there was higher hazard of PAD in participants with self-reported tooth loss because of periodontal disease (hazard ratio:1.54 [95% CI:1.20-1.98]), history of periodontal disease treatment (1.37 [1.05-1.80]), and periodontal disease diagnosis (1.38 [1.09-1.74]), compared to their respective counterparts. The clinical measure of periodontal disease (n = 5,872) was not significantly associated with incident PAD in the fully adjusted model (e.g., 1.53 [0.94-2.50] in CDC-AAP-defined severe periodontal disease versus no disease). Conclusion We observed a modest association of self-reported periodontal disease, especially when resulting in tooth loss, with incident PAD in the general population. Nonetheless, a larger study with the clinical measure of periodontal disease is warranted.
引用
收藏
页码:943 / 953
页数:11
相关论文
共 46 条
[1]   Genetic Susceptibility Contributing to Periodontal and Cardiovascular Disease [J].
Aarabi, G. ;
Zeller, T. ;
Seedorf, H. ;
Reissmann, D. R. ;
Heydecke, G. ;
Schaefer, A. S. ;
Seedorf, U. .
JOURNAL OF DENTAL RESEARCH, 2017, 96 (06) :610-617
[2]   Periodontitis is associated with the risk of subclinical atherosclerosis and peripheral arterial disease in Korean adults [J].
Ahn, Yoo-Been ;
Shin, Myung-Seop ;
Han, Dong-Hun ;
Sukhbaatar, Munkhzaya ;
Kim, Mi-Sun ;
Shin, Hye-Sun ;
Kim, Hyun-Duck .
ATHEROSCLEROSIS, 2016, 251 :311-318
[3]   Periodontitis deteriorates peripheral arterial disease in Japanese population via enhanced systemic inflammation [J].
Aoyama, Norio ;
Suzuki, Jun-ichi ;
Kobayashi, Naho ;
Hanatani, Tomoya ;
Ashigaki, Norihiko ;
Yoshida, Asuka ;
Shiheido, Yuka ;
Sato, Hiroki ;
Kumagai, Hidetoshi ;
Ikeda, Yuichi ;
Akazawa, Hiroshi ;
Komuro, Issei ;
Izumi, Yuichi ;
Isobe, Mitsuaki .
HEART AND VESSELS, 2017, 32 (11) :1314-1319
[4]   In search of appropriate measures of periodontal status: The Periodontal Profile Phenotype (P3) system [J].
Beck, James D. ;
Moss, Kevin L. ;
Morelli, Thiago ;
Offenbacher, Steven .
JOURNAL OF PERIODONTOLOGY, 2018, 89 (02) :166-175
[5]   Periodontal disease and coronary heart disease - A reappraisal of the exposure [J].
Beck, JD ;
Eke, P ;
Heiss, G ;
Madianos, P ;
Couper, D ;
Lin, DM ;
Moss, K ;
Elter, J ;
Offenbacher, S .
CIRCULATION, 2005, 112 (01) :19-24
[6]   Relationship of periodontal disease to carotid artery intima-media wall thickness - The atherosclerosis risk in communities (ARIC) study [J].
Beck, JD ;
Elter, JR ;
Heiss, G ;
Couper, D ;
Mauriello, SM ;
Offenbacher, S .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (11) :1816-1822
[7]   Validation of self-reported periodontal disease: A systematic review [J].
Blicher, B ;
Joshipura, K ;
Eke, P .
JOURNAL OF DENTAL RESEARCH, 2005, 84 (10) :881-890
[8]  
Borojevic Tea, 2012, Mater Sociomed, V24, P274, DOI 10.5455/msm.2012.24.274-276
[9]   Socioeconomic disadvantage and periodontal disease: The dental atherosclerosis risk in communities study [J].
Borrell, LN ;
Beck, JD ;
Heiss, G .
AMERICAN JOURNAL OF PUBLIC HEALTH, 2006, 96 (02) :332-339
[10]   Association of peripheral arterial disease with periodontal disease: analysis of inflammatory cytokines and an acute phase protein in gingival crevicular fluid and serum [J].
Calapkorur, M. Unlu ;
Alkan, B. A. ;
Tasdemir, Z. ;
Akcali, Y. ;
Saatci, E. .
JOURNAL OF PERIODONTAL RESEARCH, 2017, 52 (03) :532-539