A TP-FRET-based two-photon fluorescent probe for ratiometric visualization of endogenous sulfur dioxide derivatives in mitochondria of living cells and tissues

被引:118
作者
Yang, Xiaoguang [1 ]
Zhou, Yibo [2 ]
Zhang, Xiufang [2 ]
Yang, Sheng [1 ]
Chen, Yun [2 ]
Guo, Jingru [1 ]
Li, Xiaoxuan [1 ]
Qing, Zhihe [1 ]
Yang, Ronghua [1 ,2 ]
机构
[1] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Changsha 410114, Hunan, Peoples R China
[2] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
关键词
SO2; DERIVATIVES; PHOSPHORESCENT PROBE; BISULFITE; STRATEGY; SULFITE; THIOLS;
D O I
10.1039/c6cc05254a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A ratiometric two-photon fluorescent probe for SO2 derivatives was first proposed based on acedan-merocyanine dyads via a TP-FRET strategy. It was successfully applied to visualization of the fluctuations of enzymatically generated SO2 derivatives in the mitochondria of HepG(2) cells and rat liver tissues using two-photon fluorescence microscopy imaging.
引用
收藏
页码:10289 / 10292
页数:4
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