Schistosomicidal Activity of the Essential Oil of Ageratum conyzoides L. (Asteraceae) against Adult Schistosoma mansoni Worms

被引：52

作者：

de Melo, Nathalya I. ^{[1
]}

Magalhaes, Lizandra G. ^{[1
]}

de Carvalho, Carlos E. ^{[1
]}

Wakabayashi, Kamila A. L. ^{[1
]}

Aguiar, Gabriela de P. ^{[1
]}

Ramos, Rafael C. ^{[1
]}

Mantovani, Andre L. L. ^{[1
]}

Turatti, Izabel C. C. ^{[2
]}

Rodrigues, Vanderlei ^{[3
]}

Groppo, Milton ^{[4
]}

Cunha, Wilson R. ^{[1
]}

Veneziani, Rodrigo C. S. ^{[1
]}

Crotti, Antonio E. M. ^{[1
]}

机构：

[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, BR-14404600 Franca, SP, Brazil

[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil

[3] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil

[4] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP, Brazil

来源：

MOLECULES | 2011年 / 16卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

Schistosoma; essential oil; Ageratum conyzoides; IN-VITRO; ANTIMICROBIAL ACTIVITIES; LEAVES; PRAZIQUANTEL; VIVO; RESISTANCE; PLANT;

D O I：

10.3390/molecules16010762

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The in vitro schistosomicidal effects of the essential oil of Ageratum conyzoides L. (Ac-EO) against adult worms of Schistosoma mansoni is reported in this paper. Concerning this activity, Ac-EO was considered to be active, but less effective than the positive control (praziquantel, PZQ) in terms of separation of coupled pairs, mortality, decrease in motor activity, and tegumental alterations. However, Ac-EO caused an interesting dose-dependent reduction in the number of eggs of S. mansoni. Precocene I (74.30%) and (E)-caryophyllene (14.23%) were identified as the two major constituents of Ac-EO. These compounds were tested individually and were found to be much less effective than Ac-EO and PZQ. A mixture of the two major compounds in a ratio similar to that found in the Ac-EO was also less effective than Ac-EO, thus revealing that there are no synergistic effects between these components. These results suggest that the essential oil of A. conyzoides is very promising for the development of new schistosomicidal agents.

引用

页码：762 / 773

页数：12

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