Improved survival after allogeneic transplantation for acute lymphoblastic leukemia in adults: a Danish population-based study

被引：2

作者：

Gjaerde, Lars Klingen ^{[1
,2
]}

Rank, Cecilie Utke ^{[1
]}

Andersen, Mette Klarskov ^{[3
]}

Jakobsen, Lasse Hjort ^{[4
,5
]}

Sengelov, Henrik ^{[1
,2
]}

Olesen, Gitte ^{[6
]}

Kornblit, Brian ^{[1
]}

Marquart, Hanne ^{[7
]}

Friis, Lone Smidstrup ^{[1
]}

Petersen, Soren Lykke ^{[1
]}

Andersen, Niels Smedegaard ^{[1
]}

Nielsen, Ove Juul ^{[1
]}

Toft, Nina ^{[1
]}

Schjodt, Ida ^{[1
]}

机构：

[1] Rigshosp, Copenhagen Univ Hosp, Dept Hematol, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[3] Copenhagen Univ Hosp, Dept Clin Genet, Rigshosp, Copenhagen, Denmark

[4] Aalborg Univ Hosp, Clin Canc Res Ctr, Dept Hematol, Aalborg, Denmark

[5] Aalborg Univ, Dept Clin Med, Aalborg, Denmark

[6] Aarhus Univ Hosp, Dept Hematol, Aarhus, Denmark

[7] Rigshosp, Dept Clin Immunol, Copenhagen, Denmark

来源：

LEUKEMIA & LYMPHOMA | 2022年 / 63卷 / 02期

关键词：

Allogeneic transplantation; allogeneic hematopoietic stem cell transplantation; acute lymphoblastic leukemia; ALL; survival; STEM-CELL TRANSPLANTATION; MINIMAL RESIDUAL DISEASE; REMISSION; MODELS; IMPACT; CHEMOTHERAPY; CYTOGENETICS; OUTCOMES; BLOOD; PCR;

D O I：

10.1080/10428194.2021.1992620

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated trends of survival in a population-based cohort study of all 181 adults who received HCT for ALL in Denmark between 2000-2019. Patients had a median (min-max) age of 36 (18-74) years at HCT and were followed for a median of eight years. Overall survival (OS) improved over time with an estimated 2-year OS of 49% (CI 27-66%) in year 2000 versus 77% (CI 59-88%) in year 2019. More patients achieved cure over time (OR for cure per year 1.07, CI 1.00-1.15), while the rate of death in non-cured patients remained stable (HR of excess mortality per year 0.99, CI 0.93-1.06). Relapse decreased over time (HR 0.92 per year, CI 0.87-0.98), whereas non-relapse mortality did not change notably (HR 0.98 per year, CI 0.93-1.04). In conclusion, survival after HCT in adults with ALL has improved over the past two decades, primarily due to more patients achieving cure.

引用

页码：416 / 425

页数：10

共 42 条

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