Ebola: Lessons on Vaccine Development

被引：37

作者：

Feldmann, Heinz ^{[1
,2
]}

Feldmann, Friederike ^{[3
]}

Marzi, Andrea ^{[1
]}

机构：

[1] NIAID, Lab Virol, Rocky Mt Labs, Div Intramural Res,NIH, Hamilton, MT 59840 USA

[2] Univ Manitoba, Dept Med Microbiol & Infect Dis, Winnipeg, MB 93E 0J9, Canada

[3] NIAID, Rocky Mt Vet Branch, Rocky Mt Labs, Div Intramural Res,NIH, Hamilton, MT 59840 USA

来源：

ANNUAL REVIEW OF MICROBIOLOGY, VOL 72 | 2018年 / 72卷

关键词：

Ebola virus; animal models; vaccines; clinical trials; challenges; lessons learned; PROTECTS NONHUMAN-PRIMATES; T-CELL RESPONSES; MARBURG VIRUS; DOUBLE-BLIND; HEALTHY-ADULTS; LETHAL EBOLA; DNA VACCINES; GUINEA-PIGS; HEMORRHAGIC-FEVER; VECTORED VACCINE;

D O I：

10.1146/annurev-micro-090817-062414

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The West African Ebola virus (EBOV) epidemic has fast-tracked countermeasures for this rare, emerging zoonotic pathogen. Until 2013-2014, most EBOV vaccine candidates were stalled between the preclinical and clinical milestones on the path to licensure, because of funding problems, lack of interest from pharmaceutical companies, and competing priorities in public health. The unprecedented and devastating epidemic propelled vaccine candidates toward clinical trials that were initiated near the end of the active response to the outbreak. Those trials did not have a major impact on the epidemic but provided invaluable data on vaccine safety, immunogenicity, and, to a limited degree, even efficacy in humans. There are plenty of lessons to learn from these trials, some of which are addressed in this review. Better preparation is essential to executing an effective response to EBOV in the future; yet, the first indications of waning interest are already noticeable.

引用

页码：423 / 446

页数：24

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