Methylated hexitol nucleic acids, towards congeners with improved antisense potential

被引：1

作者：

Van Aerschot, A ^{[1
]}

Marchand, A ^{[1
]}

Schepers, G ^{[1
]}

Van den Eynde, W ^{[1
]}

Rozenski, J ^{[1
]}

Busson, R ^{[1
]}

Herdewijn, P ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Med Chem Lab, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期

关键词：

D O I：

10.1081/NCN-120022842

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In an effort to further improve the hybridisation potential of anhydro-hexitol nucleoside analogues, the 1'-methoxyl and 3'-methoxyl substituents were introduced and evaluated for their antisense potential. In view of the selectivity of pairing with RNA, especially the introduction of a 3'-O-alkyl moiety deserves further study.

引用

页码：1227 / 1229

页数：3