Rhodiasolv PolarClean - a greener alternative in solid-phase peptide synthesis

被引：22

作者：

Kumar, Ashish ^{[1
,2
]}

Sharma, Anamika ^{[1
,2
]}

de la Torre, Beatriz G. ^{[2
]}

Albericio, Fernando ^{[1
,3
,4
,5
]}

机构：

[1] Univ KwaZulu Natal, Sch Chem & Phys, Peptide Sci Lab, ZA-4001 Durban, South Africa

[2] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, KwaZulu Natal Res Innovat & Sequencing Platform K, ZA-4041 Durban, South Africa

[3] Univ Barcelona, BBN Networking Ctr Bioengn Biomat & Nanomed, CIBER BBN, Barcelona, Spain

[4] Univ Barcelona, Dept Organ Chem, Barcelona, Spain

[5] CSIC, Inst Adv Chem Catalonia IQAC, Barcelona, Spain

来源：

GREEN CHEMISTRY LETTERS AND REVIEWS | 2021年 / 14卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Fluorenylmethoxycarbonyl (Fmoc); Green solvent; peptide; polystyrene resin; supported chemistry; GAMMA-VALEROLACTONE GVL; EFFICIENT SYNTHESIS; SOLVENT;

D O I：

10.1080/17518253.2021.1965663

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives. It can also swell polystyrene and ChemMatrix, the two resins most widely used in solid-phase peptide synthesis. The synthesis of model peptides has been carried out, rendering the target peptide as a major component. The performance of PolarClean demonstrates its utility in the toolbox for Green Solid-Phase Peptide Synthesis.

引用

收藏

页码：544 / 549

页数：6

相关论文

共 50 条

[41] Chemical Synthesis of Six-Atom Thioether Bridged Diaminodiacid for Solid-Phase Synthesis of Peptide Disulfide Bond Mimics [J].

Chen, Junyou ;

Sun, Shuaishuai ;

Zhao, Rui ;

Xi, Chen-Peng ;

Qiu, Wenjie ;

Wang, Ning ;

Wang, Ya ;

Bierer, Donald ;

Shi, Jing ;

Li, Yi-Ming .

CHEMISTRYSELECT, 2020, 5 (04) :1359-1363

[42] Direct Solid-Phase Synthesis of the β-Amyloid (1-42) Peptide Using Controlled Microwave Heating [J].

Bacsa, Bernadett ;

Bosze, Szilvia ;

Kappe, C. Oliver .

JOURNAL OF ORGANIC CHEMISTRY, 2010, 75 (06) :2103-2106

[43] Total Solid-Phase Synthesis of Dehydroxy Fengycin Derivatives [J].

Roses, Cristina ;

Camo, Cristina ;

Oliveras, Angel ;

Moll, Lluis ;

Lopez, Nerea ;

Feliu, Lidia ;

Planas, Marta .

JOURNAL OF ORGANIC CHEMISTRY, 2018, 83 (24) :15297-15311

[44] Solid-phase synthesis of base-sensitive oligonucleotides [J].

Virta, Pasi .

ARKIVOC, 2009, :54-83

[45] Solid-Phase Synthesis and Circular Dichroism Study of -ABpeptoids [J].

Sable, Ganesh A. ;

Lee, Kang Ju ;

Lim, Hyun-Suk .

MOLECULES, 2019, 24 (01)

[46] Solid-Phase Synthesis of Cyclic Octapeptide Phakellistatin 15 [J].

Li, Yu-lei ;

Wu, Ming-hao ;

Chang, Qi ;

Zhao, Xia .

CHEMISTRY OF NATURAL COMPOUNDS, 2019, 55 (03) :520-524

[47] Solid-Phase Synthesis of (Poly)phosphorylated Nucleosides and Conjugates [J].

Tonn, Viktoria Caroline ;

Meier, Chris .

CHEMISTRY-A EUROPEAN JOURNAL, 2011, 17 (35) :9832-9842

[48] Solid-Phase Synthesis of N-Aryl Succinimides [J].

Rad-Moghadam, Kurosh ;

Kheyrkhah, Leila .

SYNTHETIC COMMUNICATIONS, 2009, 39 (12) :2108-2115

[49] Modular Solid-Phase Synthesis of Antiprotozoal Barnesin Derivatives [J].

Roman, David ;

Raguz, Luka ;

Keiff, Francois ;

Meyer, Florian ;

Barthels, Fabian ;

Schirmeister, Tanja ;

Kloss, Florian ;

Beemelmanns, Christine .

ORGANIC LETTERS, 2020, 22 (10) :3744-3748

[50] The depsipeptide method for solid-phase synthesis of difficult peptides [J].

Coin, Irene .

JOURNAL OF PEPTIDE SCIENCE, 2010, 16 (05) :223-230

← 1 2 3 4 5 →