Rhodiasolv PolarClean - a greener alternative in solid-phase peptide synthesis

被引：22

作者：

Kumar, Ashish ^{[1
,2
]}

Sharma, Anamika ^{[1
,2
]}

de la Torre, Beatriz G. ^{[2
]}

Albericio, Fernando ^{[1
,3
,4
,5
]}

机构：

[1] Univ KwaZulu Natal, Sch Chem & Phys, Peptide Sci Lab, ZA-4001 Durban, South Africa

[2] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, KwaZulu Natal Res Innovat & Sequencing Platform K, ZA-4041 Durban, South Africa

[3] Univ Barcelona, BBN Networking Ctr Bioengn Biomat & Nanomed, CIBER BBN, Barcelona, Spain

[4] Univ Barcelona, Dept Organ Chem, Barcelona, Spain

[5] CSIC, Inst Adv Chem Catalonia IQAC, Barcelona, Spain

来源：

GREEN CHEMISTRY LETTERS AND REVIEWS | 2021年 / 14卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Fluorenylmethoxycarbonyl (Fmoc); Green solvent; peptide; polystyrene resin; supported chemistry; GAMMA-VALEROLACTONE GVL; EFFICIENT SYNTHESIS; SOLVENT;

D O I：

10.1080/17518253.2021.1965663

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives. It can also swell polystyrene and ChemMatrix, the two resins most widely used in solid-phase peptide synthesis. The synthesis of model peptides has been carried out, rendering the target peptide as a major component. The performance of PolarClean demonstrates its utility in the toolbox for Green Solid-Phase Peptide Synthesis.

引用

页码：544 / 549

页数：6

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