PMMA-Based Bone Cements and the Problem of Joint Arthroplasty Infections: Status and New Perspectives

被引:80
作者
Bistolfi, Alessandro [1 ]
Ferracini, Riccardo [2 ]
Albanese, Carlo [1 ]
Verne, Enrica [3 ]
Miola, Marta [3 ]
机构
[1] AO Citta Salute & Sci, CTO Hosp, Dept Orthoped, Via Zuretti 29, I-10126 Turin, Italy
[2] Univ Genoa, Dept Surg Sci & Integrated Diagnost, IRCCS Osped Policlin San Martino, Largo R Benzi 10, I-16132 Genoa, Italy
[3] Politecn Torino, PolitoBIOMed Lab, Dept Appl Sci & Technol, Cso Duca Abruzzi 24, I-10129 Turin, Italy
关键词
polymethyl methacrylate-based bone cement; additives; antibiotics; antibacterial; bioactive; IN-VITRO; MECHANICAL-PROPERTIES; ANTIMICROBIAL ACTIVITY; ANTIBACTERIAL; RELEASE; GENTAMICIN; BIOACTIVITY;
D O I
10.3390/ma12234002
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Polymethyl methacrylate (PMMA)-based bone cement is a biomaterial that has been used over the last 50 years to stabilize hip and knee implants or as a bone filler. Although PMMA-based bone cement is widely used and allows a fast-primary fixation to the bone, it does not guarantee a mechanically and biologically stable interface with bone, and most of all it is prone to bacteria adhesion and infection development. In the 1970s, antibiotic-loaded bone cements were introduced to reduce the infection rate in arthroplasty; however, the efficiency of antibiotic-containing bone cement is still a debated issue. For these reasons, in recent years, the scientific community has investigated new approaches to impart antibacterial properties to PMMA bone cement. The aim of this review is to summarize the current status regarding antibiotic-loaded PMMA-based bone cements, fill the gap regarding the lack of data on antibacterial bone cement, and explore the progress of antibacterial bone cement formulations, focusing attention on the new perspectives. In particular, this review highlights the innovative study of composite bone cements containing inorganic antibacterial and bioactive phases, which are a fascinating alternative that can impart both osteointegration and antibacterial properties to PMMA-based bone cement.
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页数:16
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