Effects of apolipoproteins C on oxidative phosphorylation in rat liver mitochondria

被引：3

作者：

Panin, LE ^{[1
]}

Shalbueva, NI ^{[1
]}

Polyakov, LM ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Biochem, Siberian Div, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2000年 / 130卷 / 08期

关键词：

mitochondria; oxidative phosphorylation; apoproteins C; palmitoyl carnitine; calcium;

D O I：

10.1007/BF02681941

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It is shown that apoC-III, but not other apoC proteins, components of very low density lipoproteins (apoC-I, apoC-II, apoC-III), reduced the rate of mitochondrial respiration in various metabolic states. This effect depended on the dose of apoprotein, type of oxidized substrate, and the presence of Ca ions in the incubation medium. ApoC-III completely blocked oxidative phosphorylation during oxidation of palmitoyl carnitine by mitochondria, while the respiration rate in metabolic state 4 remained unchanged.

引用

页码：769 / 771

页数：3