Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDMS and IDDM8

被引：127
作者：
Luo, DF
Buzzetti, R
Rotter, JI
MacLaren, NK
Raffel, LJ
Nistico, L
Giovannini, C
Pozzilli, P
Thomson, G
She, JX
机构：
[1] UNIV FLORIDA,COLL MED,DEPT PATHOL IMMUNOL & LAB MED,GAINESVILLE,FL 32610
[2] UNIV FLORIDA,COLL MED,CTR MAMMALIAN GENET,GAINESVILLE,FL
[3] UNIV ROMA LA SAPIENZA,IST CLIN MED 2,ROME,ITALY
[4] UNIV CALIF LOS ANGELES,LOS ANGELES,CA 90024
[5] CEDAR SINAI MED RES INST,DEPT PEDIAT & MED,LOS ANGELES,CA
[6] UNIV CALIF BERKELEY,DEPT INTEGRAT BIOL,BERKELEY,CA 94720
来源：
HUMAN MOLECULAR GENETICS | 1996年 / 5卷 / 05期
关键词：
D O I：
10.1093/hmg/5.5.693
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Previous genome-wide mapping studies have provided suggestive linkage evidence for several novel susceptibility loci responsible for insulin-dependent diabetes mellitus (IDDM); however, the evidence was not sufficient to confirm the existence of these genes, We analyzed 265 Caucasian families with IDDM and report the first evidence that meets the standard for confirmed linkage for three susceptibility loci, The maximum LOD scores (MLS) were 3.9, 4.5 and 3.6 in our data set, and 5.0, 4.6 and 5.0 for our data combined with non-overlapping data from the literature, for IDDM4 on chromosome 11q13, IDDM5 on 6q25, and IDDM8 on 6q27, respectively, However, we could not confirm linkage for IDDM3 on 15q26 and IDDM7 on 2q31-q33, or linkage disequilibrium between D2S152 and IDDM7.
引用
收藏
页码：693 / 698
页数：6
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