Dihydroartemisinin inhibits cell proliferation by induced G1 arrest and apoptosis in human nasopharyngealcarcinoma cells

被引：14

作者：

Huang, Zhenhe ^{[1
]}

Huang, Xueqin ^{[2
]}

Jiang, Donghui ^{[4
]}

Zhang, Yuefei ^{[3
,4
]}

Huang, Bo ^{[4
]}

Luo, Guoqing ^{[3
,4
]}

机构：

[1] Ganzhou Peoples Hosp, Dept Otolaryngol, Ganzhou 341000, Jiangxi, Peoples R China

[2] Guangdong Med Coll, Clin Coll 2, Dongguan, Guangdong, Peoples R China

[3] Guangdong Med Coll, Dept Otolaryngol, Zhanjiang 524023, Guangdong, Peoples R China

[4] Guangdong Med Coll, Affiliated Hosp 1, Zhanjiang 524023, Guangdong, Peoples R China

来源：

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | 2016年 / 12卷 / 01期

关键词：

Cancer; dihydroartemisinin; nasopharyngeal carcinoma; natural compound; EPSTEIN-BARR-VIRUS; GROWTH-INHIBITION; CARCINOMA-CELLS; CYCLE ARREST; CANCER; ARTEMISININ; ARTESUNATE; EXPRESSION;

D O I：

10.4103/0973-1482.151855

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Context: Dihydroartemisinin (DHA) exhibits anticancer activity in a number of human cancer cells. However, it is still unknown whether DHA has anticancer effect on nasopharyngeal cancer (NPC) cells. Aims: To investigate the anticancer activity of DHA on CNE-2 cells. Materials and Methods: Cell cycleand invasion assay were used to detect the effect of DHA on CNE-2 cells. Protein molecular differences were examined by Western blot. Results: DHA strongly inhibited cell proliferation by induced cell cycle G1 arrest and apoptosis in CNE-2 cells. In addition, cell motility, invasion, and colony formation were suppressed by DHA. Conclusions: DHA shows significant anticancer effects on human NPC cells, and may be a preventive and therapeutic agent against NPC.

引用

页码：244 / 247

页数：4

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