Dihydroartemisinin inhibits cell proliferation by induced G1 arrest and apoptosis in human nasopharyngealcarcinoma cells

被引：14
|
作者：
Huang, Zhenhe [1 ]
Huang, Xueqin [2 ]
Jiang, Donghui [4 ]
Zhang, Yuefei [3 ,4 ]
Huang, Bo [4 ]
Luo, Guoqing [3 ,4 ]
机构：
[1] Ganzhou Peoples Hosp, Dept Otolaryngol, Ganzhou 341000, Jiangxi, Peoples R China
[2] Guangdong Med Coll, Clin Coll 2, Dongguan, Guangdong, Peoples R China
[3] Guangdong Med Coll, Dept Otolaryngol, Zhanjiang 524023, Guangdong, Peoples R China
[4] Guangdong Med Coll, Affiliated Hosp 1, Zhanjiang 524023, Guangdong, Peoples R China
来源：
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | 2016年 / 12卷 / 01期
关键词：
Cancer; dihydroartemisinin; nasopharyngeal carcinoma; natural compound; EPSTEIN-BARR-VIRUS; GROWTH-INHIBITION; CARCINOMA-CELLS; CYCLE ARREST; CANCER; ARTEMISININ; ARTESUNATE; EXPRESSION;
D O I：
10.4103/0973-1482.151855
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Context: Dihydroartemisinin (DHA) exhibits anticancer activity in a number of human cancer cells. However, it is still unknown whether DHA has anticancer effect on nasopharyngeal cancer (NPC) cells. Aims: To investigate the anticancer activity of DHA on CNE-2 cells. Materials and Methods: Cell cycleand invasion assay were used to detect the effect of DHA on CNE-2 cells. Protein molecular differences were examined by Western blot. Results: DHA strongly inhibited cell proliferation by induced cell cycle G1 arrest and apoptosis in CNE-2 cells. In addition, cell motility, invasion, and colony formation were suppressed by DHA. Conclusions: DHA shows significant anticancer effects on human NPC cells, and may be a preventive and therapeutic agent against NPC.
引用
收藏
页码：244 / 247
页数：4
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