Asymmetric [3+2] Cycloadditions of Allenoates and Dual Activated Olefins Catalyzed by Simple Bifunctional N-Acyl Aminophosphines

被引：273

作者：

Xiao, Hua ^{[1
]}

Chai, Zhuo ^{[2
]}

Zheng, Chang-Wu ^{[2
]}

Yang, Ying-Quan ^{[1
]}

Liu, Wen ^{[1
]}

Zhang, Jun-Kang ^{[2
]}

Zhao, Gang ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 26期

基金：

中国国家自然科学基金;

关键词：

asymmetric catalysis; cycloaddition; olefins; organocatalysis; phosphanes; BAYLIS-HILLMAN REACTIONS; ELECTRON-DEFICIENT OLEFINS; MODIFIED ALLYLIC COMPOUNDS; QUATERNARY CARBON CENTERS; METHYL VINYL KETONE; 4+2 ANNULATION; ENANTIOSELECTIVE SYNTHESIS; SULFONATED IMINES; PHOSPHINE; 2,3-BUTADIENOATES;

D O I：

10.1002/anie.201000446

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Bifunctional catalyst: Simple bifunctional N-Acyl aminophosphines such as 1 were developed to catalyze the first asymmetric [3+2] cycloaddition between allenoates and dual activated olefins. The cycloaddi- tion reactions afford multifunctional chiral cyclopentenes with exclusive regioselectivity, and good to excellent enantioselectivity and yields. © 2010 Wlley-VCH Verlag GmbH &. Co. KGaA, Weinheim.

引用

页码：4467 / 4470

页数：4

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