Bayesian adaptive biased-coin designs for clinical trials with normal responses

被引:55
作者
Atkinson, AC
Biswas, A
机构
[1] Univ London London Sch Econ & Polit Sci, Dept Stat, London WC2A 2AE, England
[2] Indian Stat Inst, Appl Stat Unit, Kolkata 700108, W Bengal, India
关键词
Bayesian biased-coin; D-A-optimal design; limiting allocation proportion; minimization; randomization; regularization;
D O I
10.1111/j.0006-341X.2005.031002.x
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Adaptive designs are used in phase III clinical trials for skewing the allocation pattern toward the better treatments. We use optimum design theory to derive a skewed Bayesian biased-coin procedure for sequential designs with continuous responses. The skewed designs are used to provide adaptive designs, the performance of which is studied numerically and theoretically. Important properties are loss and the proportion of allocation to the better treatment.
引用
收藏
页码:118 / 125
页数:8
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