Leptin action in the midbrain: From reward to stress

被引：14
作者：
Xu, Lu [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Anat, NL-6500 HB Nijmegen, Netherlands
来源：
JOURNAL OF CHEMICAL NEUROANATOMY | 2014年 / 61-62卷
关键词：
Nutrition status; Midbrain; Dopamine neurons; Addiction; VENTRAL TEGMENTAL AREA; EDINGER-WESTPHAL NUCLEUS; AMPHETAMINE-REGULATED TRANSCRIPT; CONDITIONED PLACE PREFERENCE; CORTICOTROPIN-RELEASING-FACTOR; CENTRAL-NERVOUS-SYSTEM; DOPAMINE-DEFICIENT MICE; HIGH-FAT DIET; MESSENGER-RNA EXPRESSION; DORSAL RAPHE NUCLEUS;
D O I：
10.1016/j.jchemneu.2014.06.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The midbrain is a heterogenous brain structure that serves important roles in feeding regulation, motivation and reward, movement and stress adaptation. One common feature of different midbrain regions is that they all express the long form of leptin receptor (LepRb). Leptin is mainly produced and secreted by white adipose tissue, informing the brain centers via LepRb about the amount of fat storage in the body. In this way, leptin exerts its action in the midbrain to regulate different functions. First, this review deals with the basic information of leptin and its signaling. Then, attention is given to various interactions of leptin with the midbrain regions, including ventral tegmental area (VIA), substantia nigra pars compacta (SNc), rostral linear raphe (RLi) and centrally-projecting Edinger-Westphal nucleus (EWcp). Also, the projection areas of these midbrain regions are discussed. Finally, the possible function of leptin in the midbrain is suggested. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：256 / 265
页数：10
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