Current landscape of immunotherapy trials in locally advanced and high-risk head and neck cancer

被引：2

作者：

Park, Robin ^{[1
]}

Park, Jong Chul ^{[2
,3
]}

机构：

[1] Tufts Univ, Dept Med, MetroWest Med Ctr, Sch Med, Framingham, MA 01702 USA

[2] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[3] Harvard Med Sch, Boston, MA 02115 USA

来源：

IMMUNOTHERAPY | 2021年 / 13卷 / 11期

关键词：

adjuvant therapy; head and neck cancer; immune checkpoint inhibitor; locally advanced; neoadjuvant therapy; SQUAMOUS-CELL CARCINOMA; AVELUMAB-CETUXIMAB-RADIOTHERAPY; RANDOMIZED PHASE-III; CHEMORADIOTHERAPY CRT; NIVOLUMAB NIVO; SAFETY PHASE; PATIENTS PTS; OPEN-LABEL; PEMBROLIZUMAB; IPILIMUMAB;

D O I：

10.2217/imt-2021-0048

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The current standard of therapy for locally advanced (LA) head and neck squamous cell carcinoma (HNSCC) is limited by toxicity and suboptimal control. The role of immunotherapy (IO) is being evaluated in the LA setting. This review aims to summarize the recent advances and the direction of clinical trials in IO in LA or high-risk HNSCC. Despite negative results in some studies, several early phase trials suggest the feasibility and efficacy of IO-based strategies in LA or high-risk HNSCC. Further refining of patient selection and biomarker development is warranted for successful incorporation of IO in this patient population.

引用

页码：931 / 940

页数：10

共 56 条

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