CuI-Catalyzed 11C Carboxylation of Boronic Acid Esters: A Rapid and Convenient Entry to 11C-Labeled Carboxylic Acids, Esters, and Amides

被引：95

作者：

Riss, Patrick J. ^{[1
,2
]}

Lu, Shuiyu ^{[2
]}

Telu, Sanjay ^{[2
]}

Aigbirhio, Franklin I. ^{[1
]}

Pike, Victor W. ^{[2
]}

机构：

[1] Univ Cambridge, Wolfson Brain Imaging Ctr, Cambridge CB2 0QQ, England

[2] NIMH, Mol Imaging Branch, Bethesda, MD 20892 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 11期

基金：

英国医学研究理事会;

关键词：

boronic acid esters; carbon-11; carboxylation; positron emission tomography; radiochemistry; MYOCARDIAL-METABOLISM; C-11; F-18; RADIOPHARMACEUTICALS; PROTEINS; ACETATE;

D O I：

10.1002/anie.201107263

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rapid and direct: The carboxylation of boronic acid esters with 11CO 2 provides [ 11C]carboxylic acids as a convenient entry into [ 11C]esters and [ 11C]amides (see scheme). This conversion of boronates is tolerant to diverse functional groups (e.g., halo, nitro, or carbonyl). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2698 / 2702

页数：5

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