Role of Dendritic Cells in Atopic Dermatitis: An Update

被引：24

作者：

Bieber, Thomas ^{[1
]}

Novak, Natalija ^{[1
]}

Herrman, Nadine ^{[1
]}

Koch, Susanne ^{[1
]}

机构：

[1] Univ Bonn, Dept Dermatol & Allergy, Med Ctr, D-53127 Bonn, Germany

来源：

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY | 2011年 / 41卷 / 03期

关键词：

Atopic dermatitis; Dendritic cells; Innate immunity; EPIDERMAL LANGERHANS CELLS; T-CELLS; INFLAMMATION; TACROLIMUS; RECEPTOR; EXPRESS; DISEASE; LESIONS; LEADS; SKIN;

D O I：

10.1007/s12016-010-8224-0

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) have been recognized as key players bridging innate and adaptive immune systems. They control the balance of the adaptive immune response, and the functional behavior of DCs is mainly dictated by their microenvironment. Atopic dermatitis (AD) is a paradigmatic disease where the inflammatory microenvironment has a deep impact on DCs. The emergence of IgE-mediated sensitization is tightly related to the impact of locally released cytokines by either keratinocytes, T cells, or other cells involved in the inflammatory reaction. This review will focus on the recent and relevant findings in the field of immunobiology of DCs and their role in AD.

引用

页码：254 / 258

页数：5

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