Role of Dendritic Cells in Atopic Dermatitis: An Update

被引：22

作者：

Bieber, Thomas ^{[1
]}

Novak, Natalija ^{[1
]}

Herrman, Nadine ^{[1
]}

Koch, Susanne ^{[1
]}

机构：

[1] Univ Bonn, Dept Dermatol & Allergy, Med Ctr, D-53127 Bonn, Germany

来源：

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY | 2011年 / 41卷 / 03期

关键词：

Atopic dermatitis; Dendritic cells; Innate immunity; EPIDERMAL LANGERHANS CELLS; T-CELLS; INFLAMMATION; TACROLIMUS; RECEPTOR; EXPRESS; DISEASE; LESIONS; LEADS; SKIN;

D O I：

10.1007/s12016-010-8224-0

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) have been recognized as key players bridging innate and adaptive immune systems. They control the balance of the adaptive immune response, and the functional behavior of DCs is mainly dictated by their microenvironment. Atopic dermatitis (AD) is a paradigmatic disease where the inflammatory microenvironment has a deep impact on DCs. The emergence of IgE-mediated sensitization is tightly related to the impact of locally released cytokines by either keratinocytes, T cells, or other cells involved in the inflammatory reaction. This review will focus on the recent and relevant findings in the field of immunobiology of DCs and their role in AD.

引用

页码：254 / 258

页数：5

共 33 条

[1] Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells [J].

Allam, Jean-Pierre ;

Peng, Wen-Ming ;

Appel, Torsten ;

Wenghoefer, Matthias ;

Niederhagen, Bernd ;

Bieber, Thomas ;

Berg, Stefaan ;

Novak, Natalija .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2008, 121 (02) :368-374

[2] Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-β1 and IL-10-producing properties [J].

Allam, Jean-Pierre ;

Wuertzen, Peter A. ;

Reinartz, Markus ;

Winter, Jochen ;

Vrtala, Susanne ;

Chen, Kuan-Wei ;

Valenta, Rudolf ;

Wenghoefer, Matthias ;

Appel, Thorsten ;

Gros, Eva ;

Niederhagen, Bernd ;

Bieber, Thomas ;

Lund, Kaare ;

Novak, Natalija .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 126 (03) :638-U5

[3] Serum IgE autoantibodies target keratinocytes in patients with atopic dermatitis [J].

Altrichter, Sabine ;

Kriehuber, Ernst ;

Moser, Julia ;

Valenta, Rudolf ;

Kopp, Tamara ;

Stingl, Georg .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2008, 128 (09) :2232-2239

[4]

Azuma M, 2010, METHODS MOL BIOL, V623, P373, DOI 10.1007/978-1-60761-588-0_24

[5] OCCURRENCE OF IGE-BEARING EPIDERMAL LANGERHANS CELLS IN ATOPIC ECZEMA - A STUDY OF THE TIME COURSE OF THE LESIONS AND WITH REGARD TO THE IGE SERUM LEVEL [J].

BIEBER, T ;

DANNENBERG, B ;

PRINZ, JC ;

RIEBER, EP ;

STOLZ, W ;

BRAUNFALCO, O ;

RING, J .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1989, 93 (02) :215-219

[6] HUMAN EPIDERMAL LANGERHANS CELLS EXPRESS THE HIGH-AFFINITY RECEPTOR FOR IMMUNOGLOBULIN-E (FC-EPSILON-RI) [J].

BIEBER, T ;

DELASALLE, H ;

WOLLENBERG, A ;

HAKIMI, J ;

CHIZZONITE, R ;

RING, J ;

HANAU, D ;

DELASALLE, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (05) :1285-1290

[7] Mechanisms of disease: Atopic dermatitis [J].

Bieber, Thomas .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (14) :1483-1494

[8] Toll-dependent selection of microbial antigens for presentation by dendritic cells [J].

Blander, JM ;

Medzhitov, R .

NATURE, 2006, 440 (7085) :808-812

[9] Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome [J].

Briot, Anais ;

Deraison, Celine ;

Lacroix, Matthieu ;

Bonnart, Chrystelle ;

Robin, Aurelie ;

Besson, Celine ;

Dubus, Pierre ;

Hovnanian, Alain .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (05) :1135-1147

[10] THE PRESENCE OF IGE MOLECULES ON EPIDERMAL LANGERHANS CELLS IN PATIENTS WITH ATOPIC-DERMATITIS [J].

BRUYNZEELKOOMEN, C ;

VANWICHEN, DF ;

TOONSTRA, J ;

BERRENS, L ;

BRUYNZEEL, PLB .

ARCHIVES OF DERMATOLOGICAL RESEARCH, 1986, 278 (03) :199-205

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