Chemically Modified Diatoms Biosilica for Bone Cell Growth with Combined Drug-Delivery and Antioxidant Properties

被引：78

作者：

Cicco, Stefania R. ^{[1
]}

Vona, Danilo ^{[2
]}

De Giglio, Elvira ^{[2
]}

Cometa, Stefania ^{[3
]}

Mattioli-Belmonte, Monica ^{[4
]}

Palumbo, Fabio ^{[5
]}

Ragni, Roberta ^{[2
]}

Farinola, Gianluca M. ^{[1
,2
]}

机构：

[1] Univ Bari Aldo Moro, Dipartimento Chim, CNR, Ist Chim Composti Organometallici, I-70125 Bari, Italy

[2] Univ Bari Aldo Moro, Dipartimento Chim, I-70125 Bari, Italy

[3] Jaber Innovat Srl, I-00100 Rome, Italy

[4] Univ Politecn Marche, Dipartimento Sci Clini & Mol, I-60126 Ancona, Italy

[5] Univ Bari Aldo Moro, Dipartimento Chim, CNR, Ist Metodol Inorgan & Plasmi, I-70125 Bari, Italy

来源：

CHEMPLUSCHEM | 2015年 / 80卷 / 07期

关键词：

biomaterials; biosilica; diatoms; drug delivery; TEMPO; MESOPOROUS SILICA NANOPARTICLES; CIPROFLOXACIN; NITROXIDE; RELEASE; FUNCTIONALIZATION; FLUOROQUINOLONES; MYELOPEROXIDASE; NANOTECHNOLOGY; POLYAMINES; PROTECTION;

D O I：

10.1002/cplu.201402398

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanostructured biosilica produced by Thalassiosira weissflogii diatoms is covalently functionalized with the cyclic nitroxide 2,6,6-tetramethylpiperidine-N-oxyl (TEMPO), an efficient scavenger of reactive oxygen species (ROS) in biological systems. Drug delivery properties of the TEMPO-functionalized biosilica are studied for Ciprofloxacin, an antimicrobial thoroughly employed in orthopedic or dental implant related infections. The resulting TEMPO-biosilica, combining Ciprofloxacin drug delivery with anti-oxidant properties, is demonstrated to be a suitable material for fibroblasts and osteoblast-like cells growth.

引用

页码：1104 / 1112

页数：9

共 79 条

[1] [Anonymous], ANGEW CHEN
[2] Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery
Argyo, Christian
Weiss, Veronika
Braeuchle, Christoph
Bein, Thomas
[J]. CHEMISTRY OF MATERIALS, 2014, 26 (01) : 435 - 451
[3] Surface-functionalized diatom microcapsules for drug delivery of water-insoluble drugs
Aw, Moom Sinn
Bariana, Manpreet
Yu, Yang
Addai-Mensah, Jonas
Losic, Dusan
[J]. JOURNAL OF BIOMATERIALS APPLICATIONS, 2013, 28 (02) : 163 - 174
[4] Tuning drug loading and release properties of diatom silica microparticles by surface modifications
Bariana, Manpreet
Aw, Moom Sinn
Kurkuri, Mahaveer
Losic, Dusan
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2013, 443 (1-2) : 230 - 241
[5] XPS analysis of glassy carbon electrodes chemically modified with 8-hydroxyquinoline-5-sulphonic acid
Brunetti, B.
De Giglio, E.
Cafagna, D.
Desimoni, E.
[J]. SURFACE AND INTERFACE ANALYSIS, 2012, 44 (04) : 491 - 496
[6] Signalling apoptosis: a radical approach
Carmody, RJ
Cotter, TG
[J]. REDOX REPORT, 2001, 6 (02) : 77 - 90
[7] Influence of enrofloxacin administration and α-tocopheryl acetate supplemented diets on oxidative stability of broiler tissues
Carreras, I
Castellari, M
Regueiro, JAG
Guerrero, L
Esteve-Garcia, E
Sárraga, C
[J]. POULTRY SCIENCE, 2004, 83 (05) : 796 - 802
[8] Surface functionalization of polypyrrole film with glucose oxidase and viologen
Cen, L
Neoh, KG
Kang, ET
[J]. BIOSENSORS & BIOELECTRONICS, 2003, 18 (04) : 363 - 374
[9] STUDIES ON BIOCHEMISTRY AND FINE STRUCTURE OF SILICA SHELL FORMATION IN DIATOMS . CHEMICAL CCMPOSITION OF NAVICULA PELLICULOSA DURING SILICON-STARVATION SYNCHRONY
COOMBS, J
DARLEY, WM
HOLMHANS.O
VOLCANI, BE
[J]. PLANT PHYSIOLOGY, 1967, 42 (11) : 1601 - &
[10] Cox EJ, 2011, CELL ORIG LIFE EXTRE, V19, P21, DOI 10.1007/978-94-007-1327-7_2

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