The acid free asymmetric intermolecular α-alkylation of aldehydes in fluorinated alcohols

被引：75
作者：
Xiao, Jian [1 ,2 ]
Zhao, Kai [1 ]
Loh, Teck-Peng [1 ]
机构：
[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 29期
关键词：
ORGANIC-REACTIONS; BOND FORMATIONS; CATALYSIS; WATER; ORGANOCATALYSIS; LIGANDS; DESIGN;
D O I：
10.1039/c2cc30261f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The acid free asymmetric intermolecular alpha-alkylation of aldehydes with alcohols has been discovered using trifluoroethanol as solvent. This unprecedented system affords the enantioenriched functionalized primary alcohols (after NaBH4 reduction) in high yields and good to excellent enantioselectivities with wide substrate scope in the absence of any acid additive.
引用
收藏
页码：3548 / 3550
页数：3
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