Combined Genetic Inactivation of β2-Microglobulin and CD58 Reveals Frequent Escape from Immune Recognition in Diffuse Large B Cell Lymphoma

被引：371

作者：

Challa-Malladi, Madhavi ^{[1
]}

Lieu, Yen K. ^{[1
]}

Califano, Olivia ^{[1
]}

Holmes, Antony B. ^{[1
]}

Bhagat, Govind ^{[2
,3
]}

Murty, Vundavalli V. ^{[1
,2
,3
]}

Dominguez-Sola, David ^{[1
]}

Pasqualucci, Laura ^{[1
,2
,3
]}

Dalla-Favera, Riccardo ^{[1
,2
,3
,4
,5
]}

机构：

[1] Columbia Univ, Inst Canc Genet, New York, NY 10032 USA

[2] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA

[3] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA

[4] Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA

[5] Columbia Univ, Dept Microbiol & Immunol, New York, NY 10032 USA

来源：

CANCER CELL | 2011年 / 20卷 / 06期

关键词：

MHC CLASS-I; ADHESION MOLECULES; HODGKIN-LYMPHOMA; T-LYMPHOCYTES; HEAVY-CHAINS; LFA-3; EXPRESSION; MUTATIONS; ANTIGEN; RECEPTOR;

D O I：

10.1016/j.ccr.2011.11.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report that diffuse large B cell lymphoma (DLBCL) commonly fails to express cell-surface molecules necessary for the recognition of tumor cells by immune-effector cells. In 29% of cases, mutations and deletions inactivate the beta 2-Microglobulin gene, thus preventing the cell-surface expression of the HLA class-I (HLA-I) complex that is necessary for recognition by CD8(+) cytotoxic T cells. In 21 A) of cases, analogous lesions involve the CD58 gene, which encodes a molecule involved in T and natural killer cell-mediated responses. In addition to gene inactivation, alternative mechanisms lead to aberrant expression of HLA-I and CD58 in >60% of DLBCL. These two events are significantly associated in this disease, suggesting that they are coselected during lymphomagenesis for their combined role in escape from immune-surveillance.

引用

页码：728 / 740

页数：13

共 50 条

[11] ANCHORING MECHANISMS FOR LFA-3 CELL-ADHESION GLYCOPROTEIN AT MEMBRANE-SURFACE [J].

DUSTIN, ML ;

SELVARAJ, P ;

MATTALIANO, RJ ;

SPRINGER, TA .

NATURE, 1987, 329 (6142) :846-848

[12] "Hard" and "soft" lesions underlying the HLA Class I alterations in cancer cells: implications for immunotherapy [J].

Garrido, Federico ;

Cabrera, Teresa ;

Aptsiauri, Natalia .

INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (02) :249-256

[13] Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma [J].

Green, Michael R. ;

Monti, Stefano ;

Rodig, Scott J. ;

Juszczynski, Przemyslaw ;

Currie, Treeve ;

O'Donnell, Evan ;

Chapuy, Bjoern ;

Takeyama, Kunihiko ;

Neuberg, Donna ;

Golub, Todd R. ;

Kutok, Jeffery L. ;

Shipp, Margaret A. .

BLOOD, 2010, 116 (17) :3268-3277

[14] Role of LFA-3, ICAM-1, and MHC class I on the of human tumor cells to LAK cells [J].

Gwin, JL ;

GercelTaylor, C ;

Taylor, DD ;

Eisenberg, B .

JOURNAL OF SURGICAL RESEARCH, 1996, 60 (01) :129-136

[15] β2-microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma [J].

Hicklin, DJ ;

Wang, ZG ;

Arienti, F ;

Rivoltini, L ;

Parmiani, G ;

Ferrone, S .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (12) :2720-2729

[16] The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile [J].

Huang, JZ ;

Sanger, WG ;

Greiner, TC ;

Staudt, LM ;

Weisenburger, DD ;

Pickering, DL ;

Lynch, JC ;

Armitage, JO ;

Wamke, RA ;

Alizadeh, AA ;

Lossos, IS ;

Levy, R ;

Chan, WC .

BLOOD, 2002, 99 (07) :2285-2290

[17] Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome [J].

Hughes, EA ;

Hammond, C ;

Cresswell, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) :1896-1901

[18] Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma [J].

Iqbal, J. ;

Greiner, T. C. ;

Patel, K. ;

Dave, B. J. ;

Smith, L. ;

Ji, J. ;

Wright, G. ;

Sanger, W. G. ;

Pickering, D. L. ;

Jain, S. ;

Horsman, D. E. ;

Shen, Y. ;

Fu, K. ;

Weisenburger, D. D. ;

Hans, C. P. ;

Campo, E. ;

Gascoyne, R. D. ;

Rosenwald, A. ;

Jaffe, E. S. ;

Delabie, J. ;

Rimsza, L. ;

Ott, G. ;

Mueller-Hermelink, H. K. ;

Connors, J. M. ;

Vose, J. M. ;

McKeithan, T. ;

Staudt, L. M. ;

Chan, W. C. .

LEUKEMIA, 2007, 21 (11) :2332-2343

[19] β2-microglobulin aberrations in diffuse large B-cell lymphoma of the testis and the central nervous system [J].

Jordanova, ES ;

Riemersma, SA ;

Philippo, K ;

Schuuring, E ;

Kluin, PM .

INTERNATIONAL JOURNAL OF CANCER, 2003, 103 (03) :393-398

[20]

KANNER SB, 1992, J IMMUNOL, V148, P2023

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