Mesenchymal stem cells immunosuppressive properties: is it specific to bone marrow-derived cells?

被引：14
作者：
Jorgensen, Christian [1 ,2 ,3 ]
机构：
[1] Hop St Eloi, Inserm, U 844, F-34295 Montpellier, France
[2] Univ Montpellier 1, UFR Med, F-34967 Montpellier, France
[3] Hop Lapeyronie, Serv Therapeut Malad Osteoarticulaires, F-34295 Montpellier, France
来源：
STEM CELL RESEARCH & THERAPY | 2010年 / 1卷
关键词：
COLLAGEN-INDUCED ARTHRITIS; TISSUE; MEMORY;
D O I：
10.1186/scrt15
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Based on their capacity to suppress immune responses, multipotent mesenchymal stromal cells (MSCs) are intensively studied for regenerative medicine. Moreover, MSCs have paracrine effects, including immunomodulation that occurs through the secretion of soluble mediators, including nitric oxide or interleukin-6, transforming growth factor-beta, human leukocyte antigen G5, and prostaglandin E(2). MSCs in the bone marrow are in close contact with T and B cells and regulate immunological memory by organizing defined numbers of dedicated survival niches for plasma cells and memory T cells in the bone marrow. All of these biological effects are probably shared by all stromal cells, including fibroblasts and stem cells isolated from exfoliated deciduous teeth. The therapeutical implications are discussed.
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