Isoketals:: highly reactive γ-ketoaldehydes formed from the H2-isoprostane pathway

被引：54

作者：

Davies, SS ^{[1
]}

Amarnath, V

Roberts, LJ

机构：

[1] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Dept Pathol, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Dept Med, Nashville, TN 37232 USA

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2004年 / 128卷 / 1-2期

关键词：

gamma-ketoaldehydes; levuglandins; oxidative injury; protein adducts; crosslinked proteins; pyrrole;

D O I：

10.1016/j.chemphyslip.2003.10.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidation of arachidonic acid leads to the formation of highly reactive gamma-ketoaldehydes now termed isoketals. Isoketals react with proteins at a rate that far exceeds other well studied products of lipid peroxidation such as 4-hydroxynonenal and demonstrate a remarkable proclivity to crosslink these proteins. For these reasons, isoketals have the potential to significantly alter protein function and contribute to disease processes. This article reviews the chemistry of isoketal formation, of their adduction to proteins. and of their proclivity to crosslink proteins, as well as their effects on protein function, and their potential role in diseases associated with oxidative injury. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：85 / 99

页数：15

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