Imines in Stille-type cross-coupling reactions:: A multicomponent synthesis of α-substituted amides

被引：43
作者：
Davis, JL [1 ]
Dhawan, R [1 ]
Arndtsen, BA [1 ]
机构：
[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 05期
关键词：
amides; imines; multicomponent reactions; palladium; Stille reaction;
D O I：
10.1002/anie.200352123
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An alternative to nucleophilic chemistry for the construction of α-substituted amides and amine derivatives from imines is provided by the Stille-type coupling of imines with organotin reagents and acid chlorides (see scheme). This Pd-catalyzed reaction is suitable for components with a range of functional groups and has been extended into a four-component-coupling reaction with carbon monoxide. dba = dibenzylideneacetone, RT = room temperature.
引用
收藏
页码：590 / 594
页数：5
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