Research and Technology in Neurocritical Care

被引:11
作者
Wijman, C. A. C. [1 ,2 ]
Smirnakis, S. M. [3 ,4 ]
Vespa, P. [5 ]
Szigeti, K. [3 ]
Ziai, W. C. [6 ]
Ning, M. M. [7 ]
Rosand, J. [8 ]
Hanley, D. F. [6 ]
Geocadin, R. [6 ]
Hall, C. [8 ]
Le Roux, P. D. [9 ]
Suarez, J. I. [3 ]
Zaidat, O. O. [10 ]
机构
[1] Stanford Univ, Med Ctr, Stanford Neurocrit Care Program, Palo Alto, CA 94304 USA
[2] Stanford Univ, Dept Neurol, Palo Alto, CA 94304 USA
[3] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA
[4] Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA
[5] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA
[6] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA
[7] Harvard Univ, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA
[8] UT SW Univ, Dept Neurol, Dallas, TX USA
[9] Univ Penn, Dept Surg, Philadelphia, PA 19104 USA
[10] Med Coll Wisconsin, Dept Neurol, Milwaukee, WI 53226 USA
关键词
Neurocritical care; Neuromonitoring; Genomics; Neuroimaging; Biomarkers; TRAUMATIC BRAIN-INJURY; CUMULATIVE RADIATION-EXPOSURE; TISSUE OXYGEN-TENSION; LEVEL-DEPENDENT MRI; CEREBRAL MICRODIALYSIS; VEGETATIVE STATE; WIDE ASSOCIATION; STROKE; REACTIVITY; PERFUSION;
D O I
10.1007/s12028-011-9609-5
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The daily practice of neurointensivists focuses on the recognition of subtle changes in the neurological examination, interactions between the brain and systemic derangements, and brain physiology. Common alterations such as fever, hyperglycemia, and hypotension have different consequences in patients with brain insults compared with patients of general medical illness. Various technologies have become available or are currently being developed. The session on "research and technology" of the first neurocritical care research conference held in Houston in September of 2009 was devoted to the discussion of the current status, and the research role of state-of-the art technologies in neurocritical patients including multi-modality neuromonitoring, biomarkers, neuroimaging, and "omics" research (proteomix, genomics, and metabolomics). We have summarized the topics discussed in this session. We have provided a brief overview of the current status of these technologies, and put forward recommendations for future research applications in the field of neurocritical care.
引用
收藏
页码:42 / 54
页数:13
相关论文
共 57 条
  • [21] Estimation of hidden state variables of the intracranial system using constrained nonlinear Kalman filters
    Hu, Xiao
    Nenov, Valeriy
    Bergsneider, Marvin
    Glenn, Thomas C.
    Vespa, Paul
    Martin, Neil
    [J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2007, 54 (04) : 597 - 610
  • [22] Blood-Oxygen Level Dependent MRI Measures of Cerebrovascular Reactivity Using a Controlled Respiratory Challenge: Reproducibility and Gender Differences
    Kassner, Andrea
    Winter, Jeff D.
    Poublanc, Julien
    Mikulis, David J.
    Crawley, Adrian P.
    [J]. JOURNAL OF MAGNETIC RESONANCE IMAGING, 2010, 31 (02) : 298 - 304
  • [23] Evolving paradigms in neuroimaging of the ischemic penumbra
    Kidwell, CS
    Alger, JR
    Saver, JL
    [J]. STROKE, 2004, 35 (11) : 2662 - 2665
  • [24] Subarachnoid hemorrhage - A preventable disease with a heritable component
    Kissela, BM
    Sauerbeck, L
    Woo, D
    Khoury, J
    Carrozzella, J
    Pancioli, A
    Jauch, E
    Moomaw, CJ
    Shukla, R
    Gebel, J
    Fontaine, R
    Broderick, J
    [J]. STROKE, 2002, 33 (05) : 1321 - 1326
  • [25] Metabolic Crisis After Traumatic Brain Injury is Associated with a Novel Microdialysis Proteome
    Lakshmanan, R.
    Loo, J. A.
    Drake, T.
    Leblanc, J.
    Ytterberg, A. J.
    McArthur, D. L.
    Etchepare, M.
    Vespa, P. M.
    [J]. NEUROCRITICAL CARE, 2010, 12 (03) : 324 - 336
  • [26] Brain function in coma, vegetative state, and related disorders
    Laureys, S
    Owen, AM
    Schiff, ND
    [J]. LANCET NEUROLOGY, 2004, 3 (09) : 537 - 546
  • [27] The physiology behind direct brain oxygen monitors and practical aspects of their use
    Maloney-Wilensky, Eileen
    Le Roux, Peter
    [J]. CHILDS NERVOUS SYSTEM, 2010, 26 (04) : 419 - 430
  • [28] Mapping cerebrovascular reactivity using blood oxygen level-dependent MRI in patients with arterial steno-occlusive disease - Comparison with arterial spin labeling MRI
    Mandell, Daniel M.
    Han, Jay S.
    Poublanc, Julien
    Crawley, Adrian P.
    Stainsby, Jeff A.
    Fisher, Joseph A.
    Mikulis, David J.
    [J]. STROKE, 2008, 39 (07) : 2021 - 2028
  • [29] Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury
    Marcoux, Judith
    McArthur, David A.
    Miller, Chad
    Glenn, Thomas C.
    Villablanca, Pablo
    Martin, Neil A.
    Hovda, David A.
    Alger, Jeffry R.
    Vespa, Paul M.
    [J]. CRITICAL CARE MEDICINE, 2008, 36 (10) : 2871 - 2877
  • [30] Recombinant activated factor VII for acute intracerebral hemorrhage
    Mayer, SA
    Brun, NC
    Begtrup, K
    Broderick, J
    Davis, S
    Diringer, MN
    Skolnick, BE
    Steiner, T
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (08) : 777 - 785