Multiple Myeloma Presenting with Autoimmune Autonomic Ganglionopathy

被引：5

作者：

Nakae, Yoshiki ^{[1
]}

Hyuga, Mizuki ^{[1
]}

Terada, Yuta ^{[2
]}

Kishimoto, Wataru ^{[1
]}

Fukunaga, Akiko ^{[1
]}

Tabata, Sumie ^{[1
]}

Maesako, Yoshitomo ^{[1
]}

Komatsu, Kenichi ^{[2
]}

Higuchi, Osamu ^{[3
]}

Nakane, Toshinari ^{[4
]}

Arima, Nobuyoshi ^{[1
]}

机构：

[1] Kitano Hosp, Dept Hematol, Tazuke Kofukai Med Res Inst, Osaka, Japan

[2] Kitano Hosp, Dept Neurol, Tazuke Kofukai Med Res Inst, Osaka, Japan

[3] Natl Hosp Org, Nagasaki Kawatana Med Ctr, Dept Clin Res, Nagasaki, Japan

[4] Kumamoto Univ, Dept Neurol, Kumamoto, Japan

来源：

INTERNAL MEDICINE | 2017年 / 56卷 / 24期

关键词：

multiple myeloma; autonomic disturbance; autoimmune autonomic ganglionopathy; HIGH-DOSE DEXAMETHASONE; GASTROINTESTINAL MOTOR DYSFUNCTION; LUPUS-ERYTHEMATOSUS; THROMBOCYTOPENIC PURPURA; LENALIDOMIDE THERAPY; BORTEZOMIB; NEUROPATHIES; EFFICACY; PHASE-2; PROFILE;

D O I：

10.2169/internalmedicine.9096-17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune autonomic ganglionopathy is an autonomic disorder that occurs as a symptom of paraneoplastic neurological syndrome. To date, there have been no reports on multiple myeloma with autoimmune autonomic ganglionopathy. A 37-year-old Japanese woman suffered from orthostatic hypotension was diagnosed with multiple myeloma (IgG kappa type), and a serological examination revealed the presence of anti-ganglionic nicotinic acetylcholine receptor (anti-gAChR) antibodies. She was treated for multiple myeloma, as a result, the autonomic disturbance improved and her anti-gAChR antibody titer decreased to undetectable levels, despite the fact that she only achieved a partial remission of multiple myeloma. Treatment for multiple myeloma may improve autoimmune autonomic ganglionopathy.

引用

页码：3347 / 3351

页数：5

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