In the era of effective antiviral chemoprophylaxis, cytomegalovirus (CMV) disease has been inconsistently associated with increased mortality in liver transplant (LT) recipients. A retrospective study evaluating the association of CMV infection and disease occurring within 1 year of transplant with the endpoints of death or the combined endpoint of graft loss or death was undertaken in a cohort of 227 CMV donor seropositive, recipient seronegative first LT recipients. Associations were evaluated using Cox proportional hazards regression models. CMV infection and disease occurred in 91 (40%) and 43 (19%) patients, respectively. Forty-eight (21%) died while 58 (26%) sustained graft loss or death. In multivariable analysis, CMV infection was associated with an increased risk of death (RR: 2.24, p = 0.008) and graft loss or death (RR: 2.85, p < 0.001). CMV disease was also associated with an increased risk of death (RR: 2.73, p = 0.003) and graft loss or death (RR: 3.04, p = 0.001). CMV infection and disease occurring within the first year after LT in high-risk recipients is associated with increased risk of death and of graft loss or death. Investigation of strategies to further reduce the risk of CMV infection and disease in high-risk LT recipients is warranted.
机构:
Mayo Clin, Div Infect Dis, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Arthurs, Supha K.
;
Eid, Albert J.
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Mayo Clin, Div Infect Dis, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Eid, Albert J.
;
Pedersen, Rachel A.
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机构:
Mayo Clin, Div Biostat, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Pedersen, Rachel A.
;
Dierichising, Ross A.
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机构:
Mayo Clin, Div Biostat, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Dierichising, Ross A.
;
Kremers, Walter K.
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机构:
Mayo Clin, Div Biostat, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Kremers, Walter K.
;
Patel, Robin
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机构:
Mayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Mayo Clin, Div Clin Microbiol, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Patel, Robin
;
Razonable, Raymund R.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Infect Dis, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA
机构:
Mayo Clin, Div Infect Dis, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Arthurs, Supha K.
;
Eid, Albert J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Infect Dis, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Eid, Albert J.
;
Pedersen, Rachel A.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Biostat, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Pedersen, Rachel A.
;
Dierichising, Ross A.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Biostat, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Dierichising, Ross A.
;
Kremers, Walter K.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Biostat, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Kremers, Walter K.
;
Patel, Robin
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Mayo Clin, Div Clin Microbiol, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA
Patel, Robin
;
Razonable, Raymund R.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Infect Dis, Rochester, MN 55905 USAMayo Clin, Div Infect Dis, Rochester, MN 55905 USA