Distortion of voiced obstruents for differential diagnosis between parkinson's disease and multiple system atrophy

被引:3
作者
Daoudi, Khalid [1 ]
Das, Biswajit [1 ]
Victor, Solange Milhe de Saint [2 ]
Foubert-Samier, Alexandra [3 ,4 ]
Pavy-Le Traon, Anne [5 ]
Rascol, Olivier [5 ]
Meissner, Wassilios G. [3 ,4 ]
Woisard, Virginie [6 ]
机构
[1] INRIA Bordeaux Sud Ouest, GeoStat Team, Bordeaux, France
[2] Univ Hosp Bordeaux, ENT Dept, Bordeaux, France
[3] Univ Hosp Bordeaux, Dept Neurol Neurodegenerat Dis, Bordeaux, France
[4] Univ Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France
[5] Univ Hosp Toulouse, Dept Neurosci & Clin Pharmacol, MSA Reference Ctr, Clin Invest Ctr CIC1436, Toulouse, France
[6] Univ Hosp Toulouse, ENT Dept, Voice & Deglutit Unit, Toulouse, France
来源
INTERSPEECH 2021 | 2021年
关键词
Parkinson's disease; Multiple system atrophy; Dysarthria; Pathological speech processing; Consonant distortion; PROGRESSIVE SUPRANUCLEAR PALSY; ACOUSTIC ANALYSIS; ONSET TIME; SPEECH; DYSARTHRIA; PATTERNS; DISORDERS;
D O I
10.21437/Interspeech.2021-223
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
Parkinson's disease (PD) and the parkinsonian variant of Multiple System Atrophy (MSA-P) are two neurodegenerative diseases which share similar clinical features, particularly in early disease stages. The differential diagnosis can be thus very challenging. Dysarthria is known to be a frequent and early clinical feature of PD and MSA. It can be thus used as a vehicle to provide a vocal biomarker which could help in the differential diagnosis. In particular, distortion of consonants is known to be a frequent impairment in these diseases. The aim of this study is to investigate distinctive patterns in the distortion of voiced obstruents (plosives and fricatives). It is the first study which attempts to examine such distortions in the French language for the purpose of the differential diagnosis between PD and MSAP (and among the very few studies if we consider all languages). We carry out a perceptual and objective analysis of voiced obstruents extracted from isolated pseudo-words initials. We first show that devoicing is a significant impairment which predominates in MSA-P. We then show that voice onset time (VOT) of voiced plosives (prevoicing duration) can be a complementary feature to improve the accuracy in discrimination between PD and MSA-P.
引用
收藏
页码:31 / 35
页数:5
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