A feedforward-feedback glucose control strategy for type 1 diabetes mellitus

被引:71
作者
Marchetti, Gianni [3 ]
Barolo, Massimiliano [3 ]
Jovanovic, Lois [2 ]
Zisser, Howard [2 ]
Seborg, Dale E. [1 ]
机构
[1] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA
[2] Sansum Diabret Res Inst, Santa Barbara, CA 93105 USA
[3] Univ Padua, Dept Chem Engn Principles & Practice, DIPIC, I-35131 Padua, Italy
关键词
diabetes; control; glucose;
D O I
10.1016/j.jprocont.2007.07.008
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
As the "artificial pancreas" becomes closer to reality, automated insulin delivery based on real-time glucose measurements becomes feasible for people with diabetes. This paper is concerned with the development of novel feedforward-feedback control strategies for realtime glucose control and type I diabetes. Improved post-meal responses can be achieved by a pre-prandial snack or bolus, or by reducing the glucose setpoint prior to the meal. Several feedforward-feed back control strategies provide attractive alternatives to the standard meal insulin bolus and are evaluated in simulations using a physiological model. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:149 / 162
页数:14
相关论文
共 49 条
[31]   Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes [J].
Nathan, DM ;
Cleary, PA ;
Backlund, JYC ;
Genuth, SM ;
Lachin, JM ;
Orchard, TJ ;
Raskin, P ;
Zinman, B .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (25) :2643-2653
[32]  
PALERM CC, 2006, P IFAC INT S ADV CON, P521
[33]   The intravenous route to blood glucose control [J].
Parker, RS ;
Doyle, FJ ;
Peppas, NA .
IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, 2001, 20 (01) :65-73
[34]   Robust H∞ glucose control in diabetes using a physiological model [J].
Parker, RS ;
Doyle, FJ ;
Ward, JH ;
Peppas, NA .
AICHE JOURNAL, 2000, 46 (12) :2537-2549
[35]   A model-based algorithm for blood glucose control in type I diabetic patients [J].
Parker, RS ;
Doyle, FJ ;
Peppas, NA .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1999, 46 (02) :148-157
[36]  
Petersen M, 2003, DIABETES CARE, V26, P917
[37]   Blood glucose control for type I diabetes mellitus:: A robust tracking H∞ problem [J].
Ruiz-Velázquez, E ;
Femat, R ;
Campos-Delgado, DU .
CONTROL ENGINEERING PRACTICE, 2004, 12 (09) :1179-1195
[38]   On-line adaptive algorithm with glucose prediction capacity for subcutaneous closed loop control of glucose: evaluation under fasting conditions in patients with Type 1 diabetes [J].
Schaller, HC ;
Schaupp, L ;
Bodenlenz, M ;
Wilinska, ME ;
Chassin, LJ ;
Wach, P ;
Vering, T ;
Hovorka, R ;
Pieber, TR .
DIABETIC MEDICINE, 2006, 23 (01) :90-93
[39]  
Seborg D. E., 2016, Process Dynamics and Control, V4th
[40]   THE EFFECT OF INTENSIVE TREATMENT OF DIABETES ON THE DEVELOPMENT AND PROGRESSION OF LONG-TERM COMPLICATIONS IN INSULIN-DEPENDENT DIABETES-MELLITUS [J].
SHAMOON, H ;
DUFFY, H ;
FLEISCHER, N ;
ENGEL, S ;
SAENGER, P ;
STRELZYN, M ;
LITWAK, M ;
WYLIEROSETT, J ;
FARKASH, A ;
GEIGER, D ;
ENGEL, H ;
FLEISCHMAN, J ;
POMPI, D ;
GINSBERG, N ;
GLOVER, M ;
BRISMAN, M ;
WALKER, E ;
THOMASHUNIS, A ;
GONZALEZ, J ;
GENUTH, S ;
BROWN, E ;
DAHMS, W ;
PUGSLEY, P ;
MAYER, L ;
KERR, D ;
LANDAU, B ;
SINGERMAN, L ;
RICE, T ;
NOVAK, M ;
SMITHBREWER, S ;
MCCONNELL, J ;
DROTAR, D ;
WOODS, D ;
KATIRGI, B ;
LITVENE, M ;
BROWN, C ;
LUSK, M ;
CAMPBELL, R ;
LACKAYE, M ;
RICHARDSON, M ;
LEVY, B ;
CHANG, S ;
HEINHEINEMANN, M ;
BARRON, S ;
ASTOR, L ;
LEBECK, D ;
BRILLON, D ;
DIAMOND, B ;
VASILASDWOSKIN, A ;
LAURENZI, B .
NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (14) :977-986