A feedforward-feedback glucose control strategy for type 1 diabetes mellitus

被引：71
作者：
Marchetti, Gianni [3 ]
Barolo, Massimiliano [3 ]
Jovanovic, Lois [2 ]
Zisser, Howard [2 ]
Seborg, Dale E. [1 ]
机构：
[1] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA
[2] Sansum Diabret Res Inst, Santa Barbara, CA 93105 USA
[3] Univ Padua, Dept Chem Engn Principles & Practice, DIPIC, I-35131 Padua, Italy
来源：
JOURNAL OF PROCESS CONTROL | 2008年 / 18卷 / 02期
关键词：
diabetes; control; glucose;
D O I：
10.1016/j.jprocont.2007.07.008
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
As the "artificial pancreas" becomes closer to reality, automated insulin delivery based on real-time glucose measurements becomes feasible for people with diabetes. This paper is concerned with the development of novel feedforward-feedback control strategies for realtime glucose control and type I diabetes. Improved post-meal responses can be achieved by a pre-prandial snack or bolus, or by reducing the glucose setpoint prior to the meal. Several feedforward-feed back control strategies provide attractive alternatives to the standard meal insulin bolus and are evaluated in simulations using a physiological model. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：149 / 162
页数：14
相关论文
共 49 条
[1]  
[Anonymous], 2005, National diabetes fact sheet
[2]  
Astrom K. J., 1995, ADAPTIVE CONTROL
[3]   The subcutaneous route to insulin-dependent diabetes therapy [J].
Bellazzi, R ;
Nucci, G ;
Cobelli, C .
IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, 2001, 20 (01) :54-64
[4]  
Bequette B Wayne, 2005, Diabetes Technol Ther, V7, P28, DOI 10.1089/dia.2005.7.28
[5]  
Bergman RN, 1997, PENN CTR N, V7, P3
[6]  
Bergman RN., 1981, CARBOHYDR METAB, V13, P269
[7]   AN ADAPTIVE PLASMA-GLUCOSE CONTROLLER BASED ON A NONLINEAR INSULIN/GLUCOSE MODEL [J].
CANDAS, B ;
RADZIUK, J .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1994, 41 (02) :116-124
[8]  
Carr K J E, 2004, J Obstet Gynaecol, V24, P382
[9]  
Chassin Ludovic J, 2005, Diabetes Technol Ther, V7, P72, DOI 10.1089/dia.2005.7.72
[10]   Expert PID control system for blood glucose control in critically Ill patients [J].
Chee, F ;
Fernando, TL ;
Savkin, AV ;
van Heeden, V .
IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE, 2003, 7 (04) :419-425
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