BEL-1, a novel clavulanic acid-inhibited extended-spectrum β-lactamase, and the class 1 integron In120 in Pseudomonas aeruginosa

被引：67

作者：

Poirel, L

Brinas, L

Verlinde, A

Ide, L

Nordmann, P

机构：

[1] Univ Paris 11, Hop Bicetre, Fac Med Paris Sud, Assistance Publ Hop Paris,Serv Bacteriol Virol, F-94275 Le Kremlin Bicetre, France

[2] Univ La Rioja, Area Bioquim & Biol Mol, Logrono 26006, Spain

[3] Heilig Hartziekenhuis Roeselare, Dept Microbiol, B-8800 Roeselare, Belgium

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 09期

关键词：

D O I：

10.1128/AAC.49.9.3743-3748.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Screening by a double-disk synergy test identified a Pseudomonas aeruginosa isolate that produced a clavulanic acid-inhibited expanded-spectrum beta-lactamase (ESBL). Cloning and sequencing identified a novel ESBL, BEL-1, weakly related to other Ambler class A ESBLs. beta-Lactamase BEL-1 hydrolyzed significantly most expanded-spectrum cephalosporins and aztreonam, and its activity was inhibited by clavulanic acid, tazobactam, cefoxitin, moxalactam, and imipenem. This chromosome-encoded ESBL gene was embedded in a class I integron containing three other gene cassettes. In addition, this integron was bracketed by Tn1404 transposon sequences at its right end and by P. aeruginosa-specific sequences at its left end.

引用

页码：3743 / 3748

页数：6

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