Rhodamine-based fluorogenic probe for imaging biological thiol

被引：98
|
作者：
Shibata, Aya [1 ]
Furukawa, Kazuhiro [1 ,2 ]
Abe, Hiroshi [1 ]
Tsuneda, Satoshi [2 ]
Ito, Yoshihiro [1 ]
机构：
[1] RIKEN, Discovery Res Inst, Nano Med Engn Lab, Wako, Saitama 3510198, Japan
[2] Waseda Univ, Dept Life Sci & Med Biosci, Shinjuku Ku, Tokyo 1698555, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 07期
关键词：
thiol; imaging; fluorescence; probe; synthesis;
D O I：
10.1016/j.bmcl.2008.03.014
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We have developed a new fluorescent probe for biological thiol. The probe was synthesized by the modi. cation of the 2,4-dinitrobenzenesulfonyl group with rhodamine 110. The selective detection of thiol species such as cysteine or glutathione was achieved in biological conditions. Moreover, the probe was successfully applied to the imaging of thiol species in living human cells. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2246 / 2249
页数：4
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