Molecular pathogenesis of ovarian clear cell carcinoma

被引：31
|
作者：
Gounaris, Ioannis [1 ]
Brenton, James D. [1 ]
机构：
[1] Canc Res UK Cambridge Inst, Cambridge CB2 0RE, England
来源：
FUTURE ONCOLOGY | 2015年 / 11卷 / 09期
关键词：
ARID1A; endometriosis; genetically engineered mouse models; glycogen; HNF1B; ovarian clear; PIK3CA cell cancer; IDENTIFIES FREQUENT MUTATION; ARID1A PROTEIN EXPRESSION; SWI/SNF-RELATED COMPLEXES; HYPOXIA-INDUCIBLE FACTOR; REMODELING GENE ARID1A; ENDOMETRIAL CANCER; THERAPEUTIC TARGET; GLYCOGEN-SYNTHESIS; TUMOR-SUPPRESSOR; PTEN EXPRESSION;
D O I：
10.2217/fon.15.45
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian clear cell carcinoma is a distinct subtype of epithelial ovarian cancer, characterized by an association with endometriosis, glycogen accumulation and resistance to chemotherapy. Key driver events, including ARID1A mutations and HNF1B overexpression, have been recently identified and their functional characterization is ongoing. Additionally, the role of glycogen in promoting the malignant phenotype is coming under scrutiny. Appreciation of the notion that ovarian clear cell carcinoma is essentially an ectopic uterine cancer will hopefully lead to improved animal models of the disease, in turn paving the way for effective treatments.
引用
收藏
页码：1389 / 1405
页数：17
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