Synthesis and Antimicrobial Activity of Some New Thioether Derivatives of Quinoxaline

被引：23
作者：
Singh, D. C. P. [1 ]
Hashim, S. R. [1 ]
Singhal, R. G. [2 ]
机构：
[1] Inst Foreign Trade & Management, Coll Pharm, Dept Pharmaceut Chem, Moradabad 244001, India
[2] Shobhit Univ, Sch Pharmaceut Sci, Meerut, Uttar Pradesh, India
来源：
E-JOURNAL OF CHEMISTRY | 2011年 / 8卷 / 02期
关键词：
Quinoxalines; 2-Chloro-N-(substituted phenyl)acetamides; 2-(2-Methylquinoxalin-3-ylthio)-N-substituted phenyl)acetamides; Antimicrobial activity;
D O I：
10.1155/2011/482831
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
2-Chloro-3-methylquinoxaline was selected as nucleus around which the molecular manipulations were carried out to get new compounds expected to possess better anti microbial activity. Various quinoxaline derivatives have been synthesized by replacing the chlorine at C-2 with a thioether linkage, which in turn attached to 2-(N-(substituted phenyl)acetamides. The synthesized compounds (5) were tested for their antimicrobial activity. Compounds 5b, 5c, 5d and 5i were found most active (comparable to the standard antibacterial Ciprofloxacin) amongst them. The structure of the compounds was confirmed on the basis of their spectral data.
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收藏
页码：635 / 642
页数：8
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