Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice

被引：40

作者：

An, Yi ^{[2
]}

Xin, Hui ^{[2
]}

Yan, Wei ^{[1
]}

Zhou, Xiaoxu ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Harbin, Peoples R China

[2] Qingdao Univ, Coll Med, Affiliated Hosp, Dept Cardiol, Qingdao, Peoples R China

来源：

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 2011年 / 63卷 / 03期

关键词：

Cisplatin; Lipid peroxidation; Nephrotoxicity; Nitrosative stress; Oxidative stress; Pravastatin; INDUCED CELL-DEATH; FREE-RADICALS; PLATINUM; CHEMOTHERAPY; TOXICITY; THERAPY; STRESS; CANCER; KINASE;

D O I：

10.1016/j.etp.2009.12.002

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

This study investigated the protective effects of pravastatin against cisplatin-induced nephrotoxicity and the possible mechanisms in mice. Pravastatin showed significant protection as evidenced by the decrease of elevated serum creatinine (CRE) and blood urea nitrogen (BUN), and improvement of histopathological injury induced by cisplatin. The formation of kidney malondialdehyde (MDA) with a concomitant reduction of reduced glutathione (GSH) were inhibited by pravastatin, while the activities of kidney superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-px) were increased. The over expressions of kidney induced nitric oxide synthase (iNOS) and nitrotyrosine (3-NT) were suppressed by pravastatin. Pravastatin suppressed cisplatin-induced p38 mitogen-activated protein kinase (MAPK) activation in the kidney of mice. These results suggest that pravastatin pre-administration can prevent the nephrotoxicity induced by cisplatin. Pravastatin may exert the protective effect via inhibiting oxidative and nitrosative stress. Crown Copyright (C) 2009 Published by Elsevier GmbH. All rights reserved.

引用

页码：215 / 219

页数：5

共 30 条

[1] Peroxynitrite reactivity with amino acids and proteins [J].

Alvarez, B ;

Radi, R .

AMINO ACIDS, 2003, 25 (3-4) :295-311

[2] Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells [J].

Arany, I ;

Megyesi, JK ;

Kaneto, H ;

Price, PM ;

Safirstein, RL .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2004, 287 (03) :F543-F549

[3] Differential roles of hydrogen peroxide and hydroxyl radical in cisplatin-induced cell death in renal proximal tubular epithelial cells [J].

Baek, SM ;

Kwon, CH ;

Kim, JH ;

Woo, JS ;

Jung, JS ;

Kim, YK .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2003, 142 (03) :178-186

[4] Systemic chemotherapy for patients with bladder cancer - current controversies and future directions [J].

Chester, JD ;

Hall, GD ;

Forster, M ;

Protheroe, AS .

CANCER TREATMENT REVIEWS, 2004, 30 (04) :343-358

[5]

Chirino Yolanda I., 2004, BMC Pharmacology, V4, P20, DOI 10.1186/1471-2210-4-20

[6] Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity [J].

Chirino, Yolanda I. ;

Pedraza-Chaverri, Jose .

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2009, 61 (03) :223-242

[7] PHARMACOLOGY OF COMPETITIVE INHIBITORS OF HMG-COA REDUCTASE [J].

CORSINI, A ;

MAGGI, FM ;

CATAPANO, AL .

PHARMACOLOGICAL RESEARCH, 1995, 31 (01) :9-27

[8]

DAUGAARD G, 1990, DAN MED BULL, V37, P1

[9]

Eiserich Jason P., 1998, Molecular Aspects of Medicine, V19, P221, DOI 10.1016/S0098-2997(99)00002-3

[10] Activation of mitogen-activated protein kinase by H2O2 - Role in cell survival following oxidant injury [J].

Guyton, KZ ;

Liu, YS ;

Gorospe, M ;

Xu, QB ;

Holbrook, NJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (08) :4138-4142

← 1 2 3 →