Solubility and peculiar thermodynamical behaviour of 2-aminobenzoic acid in aqueous binary solvent mixtures at 288.15 to 308.15 K

The equilibrium saturated solubility of 2-aminobenzoic acid (2-AA) in water and aqueous dimethylformamide (DMF), acetonitrile (ACN), dimethylsulfoxide (DMSO) are determined using 'formol titrimetric' method at five temperatures under atmospheric pressure and normal pH of the solutions. The solubility are analyzed to investigate the temperature effect and a comparative study to justify the effect of solvent on solubility and solvation thermodynamics of 2-AA. The saturated solubility data are used to resolve the transfer Gibbs energies Delta G(t)(0)(i), and entropies Delta S-t(0)(i), of 2-AA in the present experimental binary solution. The chemical contributions for solvent-solvent and solute-solvent interactions via free energies (Delta G(t, ch)(0)(i)) and entropies (T Delta S-t, ch(0)(i)) of transfer of 2-AA are evaluated by eliminating the cavity and dipole-dipole interactions effects from the total transfer energies. Finally the solubility, physicochemical and other thermodynamical properties of 2-AA in aqueous-organic solvent mixtures are described to clarify the chemical stability of 2-AA. The results are found in this study are very essential for biochemistry, pharmaceutical sciences, industrial design and for further theoretical studies. (C) 2020 Elsevier B.V. All rights reserved.