Effect of chronic haloperidol treatment on synaptic protein mRNAs in the rat brain

被引：31
|
作者：
Nakahara, T [1 ]
Nakamura, K
Tsutsumi, T
Hashimoto, K
Hondo, H
Hisatomi, S
Motomura, K
Uchimura, H
机构：
[1] Kyushu Univ, Fac Sci, Dept Chem, Fukuoka 8108560, Japan
[2] Hizen Natl Mental Hosp, Ctr Emot & Behav Disorder, Neurochem Lab, Saga 8420192, Japan
来源：
MOLECULAR BRAIN RESEARCH | 1998年 / 61卷 / 1-2期
关键词：
haloperidol; synaptobrevin; synaptotagmin; syntaxin; Rab; 3A; nucleus accumbens;
D O I：
10.1016/S0169-328X(98)00230-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Chronic haloperidol treatment caused significant decreases in the levels of synaptotagmin I and IV, synaptobrevin II, syntaxin 1A and Rab 3A mRNAs in the nucleus accumbens but not in the prefrontal cortex medial field, striatum, substantia nigra and ventral tegmental area. No significant changes in SNAP 25 and synaptophysin mRNA levels were observed in any brain region examined. The reduced expression of synaptic proteins may be related to haloperidol-induced depolarization block of mesolimbic dopamine neurons. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：238 / 242
页数：5
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