The applications of catalytic asymmetric halocyclization in natural product synthesis

被引：26

作者：

Yan, Jiahang ^{[1
]}

Zhou, Zhiqiang ^{[1
]}

He, Qiaoqiao ^{[1
]}

Chen, Guzhou ^{[1
]}

Wei, Hongbo ^{[1
]}

Xie, Weiqing ^{[1
,2
]}

机构：

[1] Northwest A&F Univ, Coll Chem & Pharm, Shaanxi Key Lab Nat Prod & Chem Biol, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China

[2] Key Lab Bot Pesticide R&D Shaanxi Prov, Yangling 712100, Shaanxi, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE TOTAL-SYNTHESIS; HALONIUM ION FORMATION; STABLE CARBONIUM-IONS; POLAR ADDITIONS; 2-BUTENE SYSTEMS; ELECTROPHILIC BROMINATION; ALPHA-CHLORINATION; BROMONIUM ION; STRATEGIES; BROMOCYCLIZATION;

D O I：

10.1039/d1qo01395e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Halocyclization of olefinic substrate enables the establishment of cyclic skeletons via intramolecular halonium-induced nucleophilic addition, which has been well utilized as a practical strategy for constructing cyclic skeletons in natural product synthesis. Recently, the renaissance and rapid evolution of organocatalysis have accelerated the development of catalytic asymmetric halocyclization. In this context, natural product synthesis powered by catalytic asymmetric halocyclization has also achieved considerable progress in recent years. In some cases, these newly developed protocols enable more concise synthetic routes for accessing enantioenriched natural products. To this end, this review summarizes the applications of catalytic asymmetric halocyclization in natural product synthesis.

引用

页码：499 / 516

页数：18

共 230 条

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