Synthesis of 6-substituted 1-deazapurine 2'-deoxyribonucleosides

被引：12

作者：

Wenzel, T ^{[1
]}

Seela, F ^{[1
]}

机构：

[1] UNIV OSNABRUCK,INST CHEM,ORGAN & BIOORGAN CHEM LAB,D-49069 OSNABRUCK,GERMANY

来源：

HELVETICA CHIMICA ACTA | 1996年 / 79卷 / 01期

关键词：

D O I：

10.1002/hlca.19960790117

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of 6-substituted 1-deazapurine 2'-deoxyribonucleosides is described. Glycosylation of the 1-deazapurine (imidazo[4,5-b]pyridine) anions with the alpha-D-halogenose 5 gives stereoselectively N-7- and N-9-regioisomers. H-1-NMR NOE and C-13-NMR spectroscopy are used for unambiguous assignment of isomers, and N-15-NMR chemical shifts are correlated with sigma(para) Hammett constants and point charges.

引用

页码：169 / 178

页数：10

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