The interplay between the intestinal microbiota and the immune system

被引：65

作者：

Lei, Yuk Man Kevin ^{[1
]}

Nair, Lekha ^{[1
]}

Alegre, Maria-Luisa ^{[1
]}

机构：

[1] Univ Chicago, Dept Med, Rheumatol Sect, Chicago, IL 60637 USA

来源：

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY | 2015年 / 39卷 / 01期

关键词：

SEGMENTED FILAMENTOUS BACTERIA; INNATE LYMPHOID-CELLS; ARYL-HYDROCARBON RECEPTOR; REGULATORY T-CELLS; COMMENSAL BACTERIA; DENDRITIC CELLS; GUT MICROBIOME; SYMBIOTIC BACTERIA; ORAL TOLERANCE; T(H)17 CELLS;

D O I：

10.1016/j.clinre.2014.10.008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The relationship between commensal microbes and their hosts has been studied for many years. Commensal microorganisms are known to have a significant role in regulating the physiology of their hosts and preventing pathogenic infections while the hosts' immune system is important in determining the composition of the microbiota. More recently, specific effects of the intestinal microbiota on the local and distal immune systems have been uncovered with important consequences for health and disease, and alterations in intestinal microbial composition has been associated with various disease states. Here, we will review the current understanding of the microbiota/immune system crosstalk, highlight the clinical consequences of changes in the microbiota and consider how to harness this symbiotic relationship to improve public health. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：9 / 19

页数：11

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