SYNTHESIS, CHARACTERIZATION AND ANTICONVULSANT ACTIVITY OF SUBSTITUTED IMIDAZOLINONE DERIVATIVES

被引：0
|
作者：
Sudha, B. Naga [1 ]
Subbaiah, N. Yella [1 ]
Raghavendra, H. G. [2 ]
Srikanth, A. M. [1 ]
Reddy, C. Venkataramana [1 ]
Manasa, A. [1 ]
机构：
[1] CES Coll Pharm, Dept Pharmaceut Chem, Kurnool 518218, Andhra Pradesh, India
[2] CES Coll Pharm, Dept Pharmacol, Kurnool 518218, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 24卷 / 02期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of glycine with benzoylchloride gave 2-benzamidoacetic acid (1) which on reaction with substituted benzaldehydes in presence of acetic anhydride and anhydrous sodium acetate gave 4-benzylidene-2-phenyloxazol-5(4H)-one derivatives (2a-h). 4-Nitrobenzohydrazide on reaction with 4-benzylidene-2-phyenyloxazol-5(4H)-ones (2a-h) in presence of pyridine yielded the final series of N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl)-4-nitrobenzamides (3a-h) respectively. All newly synthesized compounds were characterized on the basis of IR, H-1 NMR and mass spectral data and screened for their anticonvulsant activity.
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页码：159 / 162
页数：4
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