An Enantioselective Approach to 2,3-Disubstituted Indolines through Consecutive Bronsted Acid/Pd-Complex-Promoted Tandem Reactions

被引：77

作者：

Duan, Ying ^{[1
]}

Chen, Mu-Wang ^{[1
]}

Ye, Zhi-Shi ^{[1
]}

Wang, Duo-Sheng ^{[1
]}

Chen, Qing-An ^{[1
]}

Zhou, Yong-Gui ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 26期

基金：

中国国家自然科学基金;

关键词：

asymmetric catalysis; Bronsted acid; hydrogenation; palladium; tandem reaction; CATALYZED ASYMMETRIC HYDROGENATION; C-3 REDUCTIVE ALKYLATION; COOPERATIVE CATALYSIS; HETEROAROMATIC-COMPOUNDS; RELAY CATALYSIS; C-H; INDOLES; ALDEHYDES; CONSTRUCTION; DERIVATIVES;

D O I：

10.1002/chem.201100576

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In tandem: A divergent and enantioselective approach to 2,3-disubstituted indolines was developed through consecutive Brønsted acid/Pd-complex- promoted tandem reactions from simple 2-substituted indoles and aldehydes in one operation to give up to 98 % ee (see scheme; R1=H, F, or Me; R 2=alkyl; R3=aryl or alkyl). Three Brønsted acid promoted steps and two Pd-catalyzed hydrogenation steps were involved in this process. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7193 / 7197

页数：5

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