BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability

被引：84

作者：

Aly, Amal ^{[1
]}

Ganesan, Shridar ^{[1
]}

机构：

[1] UMDNJ, Robert Wood Johnson Med Sch, Canc Inst New Jersey, New Brunswick, NJ 08903 USA

来源：

JOURNAL OF MOLECULAR CELL BIOLOGY | 2011年 / 3卷 / 01期

基金：

美国国家卫生研究院;

关键词：

DNA repair; BRCA1; 53BP1; PARP; STRAND BREAK REPAIR; DNA-DAMAGE RESPONSE; POLY(ADP-RIBOSE) POLYMERASE PARP-1; HOMOLOGOUS RECOMBINATION REPAIR; EARLY EMBRYONIC LETHALITY; TUMOR-SUPPRESSOR GENE; INTERACT IN-VIVO; MAMMARY-TUMORS; CANCER-CELLS; BRCA1-DEFICIENT MICE;

D O I：

10.1093/jmcb/mjq055

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

BRCA1 plays a critical role in the regulation of homologous recombination (HR)-mediated DNA double-strand break repair. BRCA1-deficient cancers have evolved to tolerate loss of BRCA1 function. This renders them vulnerable to agents, such as PARP inhibitors, that are conditionally 'synthetic lethal' with their underlying repair defect. Recent studies demonstrate that BRCA1-deficient cells may acquire resistance to these agents by partially correcting their defect in HR-mediated repair, either through reversion mutations in BRCA1 or through 'synthetic viable' loss of 53BP1. These findings and their clinical implications will be reviewed in this article.

引用

页码：66 / 74

页数：9

共 109 条

[21]

Cressman VL, 1999, CELL GROWTH DIFFER, V10, P1

[22] 53BP1 facilitates long-range DNA end-joining during V(D)J recombination [J].

Difilippantonio, Simone ;

Gapud, Eric ;

Wong, Nancy ;

Huang, Ching-Yu ;

Mahowald, Grace ;

Chen, Hua Tang ;

Kruhlak, Michael J. ;

Callen, Elsa ;

Livak, Ferenc ;

Nussenzweig, Michel C. ;

Sleckman, Barry P. ;

Nussenzweig, Andre .

NATURE, 2008, 456 (7221) :529-U57

[23] Efficient transposition of the piggyBac resource (PB) transposon in mammalian cells and mice [J].

Ding, S ;

Wu, XH ;

Li, G ;

Han, M ;

Zhuang, Y ;

Xu, T .

CELL, 2005, 122 (03) :473-483

[24] A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage [J].

El-Khamisy, SF ;

Masutani, M ;

Suzuki, H ;

Caldecott, KW .

NUCLEIC ACIDS RESEARCH, 2003, 31 (19) :5526-5533

[25] Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy [J].

Farmer, H ;

McCabe, N ;

Lord, CJ ;

Tutt, ANJ ;

Johnson, DA ;

Richardson, TB ;

Santarosa, M ;

Dillon, KJ ;

Hickson, I ;

Knights, C ;

Martin, NMB ;

Jackson, SP ;

Smith, GCM ;

Ashworth, A .

NATURE, 2005, 434 (7035) :917-921

[26] DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1 [J].

Fernandez-Capetillo, O ;

Chen, HT ;

Celeste, A ;

Ward, I ;

Romanienko, PJ ;

Morales, JC ;

Naka, K ;

Xia, ZF ;

Camerini-Otero, RD ;

Motoyama, N ;

Carpenter, PB ;

Bonner, WM ;

Chen, JJ ;

Nussenzweig, A .

NATURE CELL BIOLOGY, 2002, 4 (12) :993-997

[27] Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in BRCA Carrier Ovarian Cancer Correlating With Platinum-Free Interval [J].

Fong, Peter C. ;

Yap, Timothy A. ;

Boss, David S. ;

Carden, Craig P. ;

Mergui-Roelvink, Marja ;

Gourley, Charlie ;

De Greve, Jacques ;

Lubinski, Jan ;

Shanley, Susan ;

Messiou, Christina ;

A'Hern, Roger ;

Tutt, Andrew ;

Ashworth, Alan ;

Stone, John ;

Carmichael, James ;

Schellens, Jan H. M. ;

de Bono, Johann S. ;

Kaye, Stan B. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15) :2512-2519

[28] Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers. [J].

Fong, Peter C. ;

Boss, David S. ;

Yap, Timothy A. ;

Tutt, Andrew ;

Wu, Peijun ;

Mergui-Roelvink, Marja ;

Mortimer, Peter ;

Swaisland, Helen ;

Lau, Alan ;

O'Connor, Mark J. ;

Ashworth, Alan ;

Carmichael, James ;

Kaye, Stan B. ;

Schellens, Jan H. M. ;

de Bono, Johann S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (02) :123-134

[29] Poly(ADP-Ribose) Polymerase Is Hyperactivated in Homologous Recombination-Defective Cells [J].

Gottipati, Ponnari ;

Vischioni, Barbara ;

Schultz, Niklas ;

Solomons, Joyce ;

Bryant, Helen E. ;

Djureinovic, Tatjana ;

Issaeva, Natalia ;

Sleeth, Kate ;

Sharma, Ricky A. ;

Helleday, Thomas .

CANCER RESEARCH, 2010, 70 (13) :5389-5398

[30] Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler [J].

Gottschalk, Aaron J. ;

Timinszky, Gyula ;

Kong, Stephanie E. ;

Jin, Jingji ;

Cai, Yong ;

Swanson, Selene K. ;

Washburn, Michael P. ;

Florens, Laurence ;

Ladurner, Andreas G. ;

Conaway, Joan W. ;

Conaway, Ronald C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (33) :13770-13774

← 1 2 3 4 5 6 7 8 9 10 →