Age-related changes in manganese superoxide dismutase activity in the cerebral cortex of senescence-accelerated prone and resistant mouse

被引：45

作者：

Kurokawa, T ^{[1
]}

Asada, S ^{[1
]}

Nishitani, S ^{[1
]}

Hazeki, O ^{[1
]}

机构：

[1] Hiroshima Univ, Fac Med, Dept Physiol Chem, Minami Ku, Hiroshima 7348551, Japan

来源：

NEUROSCIENCE LETTERS | 2001年 / 298卷 / 02期

关键词：

manganese superoxide dismutase; oxidative stress; lipid peroxide; cerebral cortex; senescence-accelerated prone mouse; 8; senescence-accelerated resistance mouse 1;

D O I：

10.1016/S0304-3940(00)01755-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this paper, we showed that the oxidative stress in bra in of senescence-accelerated prone mouse 8 (SAMP8) at earlier stages was increased compared with that of senescence-accelerated resistant mouse 1 (SAMR1) irrespective of the breeding conditions. Furthermore, we found that manganese superoxide dismutase (Mn-SOD) activity in the cerebral cortex of 10-week-old SAMP8 was decreased by about 50% compared with that in age-matched SAMR1, These results indicate that the decrease of Mn-SOD activity may be involved in the increased oxidative stress in the brain of SAMP8 at younger stages. However, there was no difference in the expression of this protein between the two strains at 10 weeks of age, suggesting that Mn-SOD protein in SAMP8 was post-translationally modified to reduce its enzymatic activity. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：135 / 138

页数：4

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