Cyclin D1 positive diffuse large B-cell lymphoma is a post-germinal center-type lymphoma without alterations in the CCND1 gene locus

被引：42

作者：

Vela-Chavez, Teresa ^{[1
,2
]}

Adam, Patrick ^{[1
]}

Kremer, Marcus ^{[2
]}

Bink, Karin ^{[3
]}

Bacon, Christopher M. ^{[4
,5
]}

Menon, Geetha ^{[5
]}

Ferry, Judith A. ^{[6
]}

Fend, Falko ^{[1
,2
]}

Jaffe, Elaine S. ^{[7
]}

Quintanilla-Martinez, Leticia ^{[1
,3
]}

机构：

[1] Univ Tubingen, Inst Pathol, Ctr Comprehens Canc, D-72076 Tubingen, Germany

[2] Tech Univ Munich, Inst Pathol, D-8000 Munich, Germany

[3] Helmholtz Ctr Munich, Inst Pathol, Oberschleissheim, Germany

[4] Newcastle Univ, No Inst Canc Res, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[5] Newcastle Tyne Hosp NHS Fdn Trust, Dept Cellular Pathol, Newcastle Upon Tyne, Tyne & Wear, England

[6] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[7] NCI, Pathol Lab, Hematopathol Sect, NIH, Bethesda, MD 20892 USA

来源：

LEUKEMIA & LYMPHOMA | 2011年 / 52卷 / 03期

关键词：

MULTIPLE-MYELOMA; PROTEIN EXPRESSION; OVEREXPRESSION; PROGRESSION; ACTIVATION; BINDING; G(1); BCL6;

D O I：

10.3109/10428194.2010.540361

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aims of this study were to analyze the incidence and morphology of cyclin D1++ DLBCL and cases of Richter transformation (RT), and to elucidate possible molecular mechanisms of cyclin D1 overexpression. Seventy-two cases of de novo DLBCL and 12 cases of RT were included in this study. Cyclin D1 positivity was found in 10/66 (15%%) cases of unselected de novo DLBCL and in 2/11 (18%%) cases of RT. Seven independently identified cases of cyclin D1++ DLBCL, including one RT, were added to the study. Centroblastic morphology was found in 17/19 (89%%) cases of cyclin D1++, most with a post-germinal center phenotype (CD10--, BCL6++, MUM1++). No alterations in the CCND1 gene indicative for a translocation t(11;14) were identified by FISH. Analysis of the MYC locus yielded gene copy alterations in five cases and no disruption of the gene locus in any case, suggesting an alternative mechanism of cyclin D1 deregulation.</.

引用

页码：458 / 466

页数：9

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